HSF2 Antibody, Biotin conjugated
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中文名稱：HSF2兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA010792LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) HSF2 Polyclonal antibody
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Uniprot No.：
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基因名：HSF2
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別名：Heat shock factor protein 2 antibody; Heat shock transcription factor 2 antibody; HSF 2 antibody; HSF2 antibody; HSF2_HUMAN antibody; HSTF 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Heat shock factor protein 2 protein (79-173AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
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基因功能參考文獻：
- Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells. PMID: 29799832
- HSF2 is a direct target of miR202 with a binding site on 3'-UTR of HSF2 mRNA in esophageal squamous cell carcinoma cells. PMID: 28277193
- This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies. PMID: 26119944
- Presented are the crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA. PMID: 26727490
- the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop. PMID: 26260034
- HSF2 can induce histone activation.Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
- HSF2 appears to be a potential novel molecular marker for ulcerative colitis PMID: 24533153
- the condensed chromatin of HSF2-deficient cells is accessible for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression. PMID: 25202032
- These results support a role for HSF2 in the pathogenesis of IA and further implicate this transcription factor as a potential therapeutic target. PMID: 23064888
- our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. PMID: 21792930
- Data show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2. PMID: 19768582
- characterization of the hsf2 gene and its 5'-flanking region PMID: 11795475
- HSF2 influences to the formation of nuclear stress granules PMID: 12865437
- HSF1 has a role in transcriptional regulation of the human RANK ligand gene PMID: 14699143
- results show hsp70i bookmarking is mediated by HSF2 which binds this promoter in mitotic cells, recruits protein phosphatase 2A & interacts with the CAP-G subunit of condensin to promote dephosphorylation & inactivation of condensin complexes PMID: 15662014
- The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198
- During mitosis, HSF2 is bound to the HSE promoter elements of other heat shock genes, including hsp90 and hsp27, and the proto-oncogene c-fos. The presence of HSF2 is important for expression of these genes. PMID: 17915561
- MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
- These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. PMID: 18570919
- NMR study of the SUMOylated DNA binding domain of HSF2 indicates that the SUMO moiety is flexible with respect to the DNA binding domain and has neither a noncovalent interface with nor a structural effect on the domain PMID: 19017645
- HSF1-HSF2 heterotrimerization regulates stress-induced transcription PMID: 19129477
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亞細胞定位：Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
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蛋白家族：HSF family
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