HSBP1 Antibody, Biotin conjugated
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中文名稱：HSBP1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA00454D0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HSBP1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Heat shock factor binding protein 1 antibody; Heat shock factor-binding protein 1 antibody; HSBP1 antibody; HSBP1_HUMAN antibody; HSF1BP antibody; Nasopharyngeal carcinoma associated antigen 13 antibody; Nasopharyngeal carcinoma-associated antigen 13 antibody; NPC A 13 antibody; NPC-A-13 antibody; NPCA 13 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Heat shock factor-binding protein 1 protein (1-75AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
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基因功能參考文獻：
- HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. PMID: 28828227
- Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. PMID: 28332148
- HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status. PMID: 24816843
- HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1 PMID: 21247889
- This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer. PMID: 18767159
- HSBP likely mediates its function through its trimerization domain. PMID: 11679589
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亞細胞定位：Nucleus.
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蛋白家族：HSBP1 family
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數據庫鏈接：
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