HPSE2 Antibody

說明書

中文名稱：

HPSE2兔多克隆抗體
貨號：

CSB-PA823898ESR1HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) HPSE2 Polyclonal antibody
Uniprot No.：

Q8WWQ2
基因名：

HPSE2
別名：

HPSE2 antibody; HPA2 antibody; Inactive heparanase-2 antibody; Hpa2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Inactive heparanase-2 protein (42-242AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
基因功能參考文獻(xiàn)：
1. The results of this study the Heparanase 2 appeared overexpressed at different stages of Alzheimer disease. PMID: 28387673
2. our results suggest that heparanase 2 functions as a tumor suppressor in bladder cancer PMID: 26968815
3. we provide evidence that Hpa2 overexpression in head and neck cancer cells markedly reduces tumor growth PMID: 27013193
4. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects. PMID: 27019315
5. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies. PMID: 26084486
6. HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction PMID: 25924634
7. Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium. PMID: 25423319
8. autonomic neural protein implicated in bladder emptying PMID: 25145936
9. High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation PMID: 24139593
10. Data indicate that the overexpression of HPSE1 and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development. PMID: 23370684
11. HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome. PMID: 21332471
12. A large region of marker homozygosity was observed at 10q24, consistent with known autosomal recessive inheritance, family consanguinity and previous genetic mapping in other families with Ochoa syndrome. PMID: 21450525
13. Studies indicate that cathepsin L as the heparanase activating protease. PMID: 21308479
14. These results indicate a regulatory effect of heparanase on TFPI and TFPI-2 in trophoblasts, suggesting a potential involvement of heparanase in early miscarriages. PMID: 20031192
15. We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome. Mutations with a loss of function in the Heparanase 2 (HPSE2) gene PMID: 20560209
16. Homozygous exonic deletions, nonsense mutations, and frameshift mutations in five further unrelated families confirmed HPSE2 as the causative gene for UFS PMID: 20560210
17. Results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase positive and HLA-A*0201 matched. PMID: 20182872
18. Heparanase 2 is involved in neoplastic proliferation, but it was not exclusively associated with the malignant process. PMID: 19955924
19. Heparanase may facilitate invasion and metastasis of gastric carcinoma cells. PMID: 15475937
20. Study demonstrating that increased heparanase expression in prostate cancer tissues is due to promoter hypomethylation and up-regulation of transcription factor EGR1. PMID: 15709168
21. Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas. PMID: 15837740
22. Heparanase expression is inversely correlated with survival of nasopharyngeal carcinoma (NPC) patients, indicating heparanase is a reliable prognostic factor, and further supports that heparanase is a valid target for the development of anti-cancer drugs. PMID: 16879396
23. HPSE plays a role in extracellular matrix remodeling and in increasing heparin-binding growth factor release during embryo implantation. PMID: 17989358
24. Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria. PMID: 18058084
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相關(guān)疾病：

Urofacial syndrome 1 (UFS1)
亞細(xì)胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Glycosyl hydrolase 79 family
組織特異性：

Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and
數(shù)據(jù)庫鏈接：

HGNC: 18374

OMIM: 236730

KEGG: hsa:60495

STRING: 9606.ENSP00000359583

UniGene: Hs.500750

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