HOXB5 Antibody

說明書

中文名稱：

HOXB5兔多克隆抗體
貨號：

CSB-PA002960
規格：

￥1090
圖片：
Western Blot analysis of HuvEc cells using HoxB5 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P09067
基因名：

HOXB5
別名：

HGNC:5116 antibody; HHO.C10 antibody; Homeo box 2A antibody; Homeo box B5 antibody; Homeobox 2A antibody; Homeobox B5 antibody; Homeobox protein HHO.C10 antibody; Homeobox protein Hox B5 antibody; Homeobox protein Hox-2A antibody; Homeobox protein Hox-B5 antibody; Homeobox protein HoxB5 antibody; Homeobox protein Hu-1 antibody; Homeobox2A antibody; HomeoboxB5 antibody; HOX 2 antibody; Hox 2.1 antibody; HOX 2A antibody; HOX B5 antibody; HOX2 antibody; Hox2.1 antibody; Hox2.1, mouse, homolog of antibody; HOX2A antibody; HOXB 5 antibody; Hoxb5 antibody; HU 1 antibody; HU1 antibody; HXB5_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human HoxB5.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. for the first time we have shown that knockdown of HOXB5 significantly inhibited non-small cell lung cancer cell proliferation, invasion, metastasis, and epithelial-mesenchymal transformation, partly through the Wnt/beta-catenin signaling pathway PMID: 28337958
2. Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. PMID: 29170127
3. HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer. PMID: 25999793
4. HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis. PMID: 26467157
5. Roles of Hoxb5 in the development of vagal and trunk neural crest cells. PMID: 25703667
6. Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. PMID: 24189625
7. HOXB5 and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions. PMID: 23438671
8. The findings for HOXB5 and PHOX2B provide supportive evidence that genes regulating ENCC proliferation, migration and differentiation could be risk factors for Hirschsprung's disease PMID: 22648184
9. A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. PMID: 22768238
10. HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. PMID: 22603795
11. Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity. PMID: 22484627
12. results support that expression of HOX genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes. PMID: 21552713
13. Data show that human HOXB5 binds to the promoter region 5' upstream of the binding site of NKX2-1 and regulates RET expression. PMID: 21677782
14. HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors PMID: 12897140
15. The expression pattern of HOXB5 correlated with the migration and differentiation of neural crest cells. PMID: 12950074
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亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family
組織特異性：

Spinal cord.
數據庫鏈接：

HGNC: 5116

OMIM: 142960

KEGG: hsa:3215

STRING: 9606.ENSP00000239151

UniGene: Hs.654456

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