HOXB3 Antibody

中文名稱：

HOXB3兔多克隆抗體
貨號：

CSB-PA010663LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA010663LA01HU diluted at 1:600 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HOXB3 Polyclonal antibody
Uniprot No.：

P14651
基因名：

HOXB3
別名：

Homeo box 2G antibody; Homeo box B3 antibody; Homeobox B3 antibody; Homeobox protein Hox-2.7 antibody; Homeobox protein Hox-2G antibody; Homeobox protein Hox-B3 antibody; Homeobox protein HoxB3 antibody; Hox 2.7 antibody; HOX 2G antibody; HOX2 antibody; Hox2.7 antibody; HOX2G antibody; HOXB3 antibody; HXB3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Homeobox protein Hox-B3 protein (315-423AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，HOXB3 Antibody (CSB-PA010663LA01HU)，的標記方式是Non-conjugated。對于HOXB3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA010663LB01HU	HOXB3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010663LC01HU	HOXB3 Antibody, FITC conjugated
Biotin	CSB-PA010663LD01HU	HOXB3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). PMID: 29439669
2. HOXB3 is degraded by miR-375 in breast cancer cells.HOXB3 plays role in tamoxifen resistance. PMID: 28075453
3. miR-10b might control cell apoptosis, proliferation, migration, and invasion in endometrial cancer via regulation of HOXB3 expression. PMID: 27447302
4. decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression PMID: 25996682
5. describe familial cases of TH in two generations (proband and his father), in addition to other two sporadic cases. We have found polymorphisms in the HOXB3, HOXD3, and a new synonymous variant, and PITX2 genes PMID: 24127533
6. HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. PMID: 23219899
7. The HOXb3 was only weakly expressed in the inv(7) positive patients. PMID: 15674412
8. RASSF1A silencing strongly correlates with overexpression of HOXB3 and DNMT3B. PMID: 19854132
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亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family
數據庫鏈接：

HGNC: 5114

OMIM: 142966

KEGG: hsa:3213

STRING: 9606.ENSP00000308252

UniGene: Hs.654560

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