HOPX Antibody, Biotin conjugated
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中文名稱：HOPX兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA859411LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HOPX Polyclonal antibody
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Uniprot No.：
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基因名：HOPX
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別名：CAMEO antibody; heart odd homeobox 1 protein antibody; HOD antibody; Homeodomain-only protein antibody; HOP antibody; HOP homeobox antibody; HOP_HUMAN antibody; HOPX antibody; LAGY antibody; Lung cancer-associated Y protein antibody; NECC1 antibody; Not expressed in choriocarcinoma clone 1 antibody; Not expressed in choriocarcinoma protein 1 antibody; OB1 antibody; odd homeobox 1 protein antibody; Odd homeobox protein 1 antibody; OTTHUMP00000158970 antibody; SMAP31 antibody; TOTO antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Homeodomain-only protein (1-73AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
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基因功能參考文獻：
- Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. PMID: 28146149
- HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis PMID: 27934959
- The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. PMID: 28723223
- HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
- HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. PMID: 28341738
- HOPX has a role in the pathogenesis of skin cancers and skin diseases. PMID: 27017330
- these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). PMID: 27112151
- HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. PMID: 27756570
- Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. PMID: 27287041
- The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. PMID: 25036325
- Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
- HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. PMID: 25345926
- GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
- HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. PMID: 22904674
- Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
- HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
- results identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90 regulation and client loading PMID: 21700222
- HOP is a novel modulator of late terminal differentiation in keratinocytes PMID: 21256618
- Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
- HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer PMID: 20228841
- HOPX is modulated by cell differentiation in human keratinocytes and this might contribute to homeostasis of keratinocytes by controlling differentiation-dependent genes. PMID: 20226564
- Loss of NECC1 expression is involved in malignant conversion of placental trophoblasts. PMID: 12573257
- Gene mapping locates LAGY on chromosome 4q11-13.1. In 72 primary lung tumors, this gene was significantly down-regulated compared to 9 normal lung tissue samples. PMID: 12759545
- One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. PMID: 14522464
- Decrease in homeodomain-only protein is associated with hypopharyngeal carcinoma PMID: 15213722
- SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls. PMID: 15307938
- loss of NECC1 expression is involved in malignant conversion of placental trophoblasts PMID: 15457851
- Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression. PMID: 16939210
- The data indicate that signaling induced by hop/STI-1 depends on endocytosis PMID: 17498662
- Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects PMID: 17576768
- HOP is a putative tumor suppressor gene that harbors tumor inhibitory activity. PMID: 18234960
- HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease PMID: 18507846
- transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to human uterine endometrial cancers (HEC) development. PMID: 19173292
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亞細胞定位：Nucleus. Cytoplasm.
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組織特異性：Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma an
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