HMGN5 Antibody
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中文名稱(chēng)：HMGN5兔多克隆抗體
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貨號(hào)：CSB-PA877299
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA877299(HMGN5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：HMGN5
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別名：High mobility group nucleosome binding domain 5 antibody; High mobility group nucleosome-binding domain-containing protein 5 antibody; Hmgn5 antibody; HMGN5_HUMAN antibody; NBP 45 antibody; NSBP 1 antibody; NSBP1 antibody; Nucleosomal binding protein 1 antibody; Nucleosome binding protein 1 antibody; Nucleosome-binding protein 1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human HMGN5
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
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基因功能參考文獻(xiàn)：
- Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy. PMID: 28341864
- High HMGN5 expression is associated with osteosarcoma invasion. PMID: 28627703
- We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma PMID: 28109076
- HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl-2. PMID: 28914995
- NSBP1 was highly expressed in NSCLC cells. NSBP1 siRNA knockdown suppressed NSCLC cell proliferation and invasion. miR326 has a putative binding site in the NSBP1 3'UTR. NSBP1 overexpression abolished miR326 inhibition of cyclin B1 and MMP9 expression. PMID: 26548724
- HMGN5 overexpression is correlated with advanced pathological grade and poorer prognosis in meningiomas PMID: 26315299
- Decreased miR-340 expression may contribute to the development and progression of prostate cancer through a mechanism that involves HMGN5. PMID: 26394192
- Our data first time identified miR-186 as the upstream regulator of NSBP1 PMID: 26290438
- High HMGN5 expression is associated with urothelial bladder cancer. PMID: 25796505
- HMGN5 is an oncogene and plays an important role in prostate cancer tumorigenesis and progression. the level of HMGN5 may be used as a biomarker to predict the patients that would benefit from gemcitabine treatment. PMID: 25572120
- HMGN5 plays an oncogenic role in human breast cancer by inhibiting cell proliferation and invasion, and activating apoptosis, which could be exploited as a target for therapy in human breast cancer. PMID: 25315189
- HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation PMID: 25307178
- HMGN5 plays oncogenic role in osteosarcoma by promoting cell proliferation and invasion, and could be exploited as a target for therapy in osteosarcoma. PMID: 24687550
- HMGN5 is a critical factor in the development of chemoresistance through regulating autophagy, and it offers a novel target for improving osteosarcoma therapy. PMID: 24664583
- Data indicate that cells lacking either high mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner. PMID: 23673662
- HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation. PMID: 22994738
- HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer. PMID: 22504871
- NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion. PMID: 22420896
- The data of study suggested that HMGN5 may play a critical role in the development of gliomas. PMID: 21373965
- these results suggest that NSBP1 promotes the viability of bladder cancer cells through increased cell proliferation PMID: 21695596
- HMGN5 has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription. PMID: 21518955
- A positive correlation was observed between NSBP1 expression and cell proliferation and apoptosis in DU145 cells. PMID: 20531280
- The structure of the HMGN5 gene and the known properties of the HMGN5 protein, are described. PMID: 20123071
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亞細(xì)胞定位：Nucleus.
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蛋白家族：HMGN family
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組織特異性：Ubiquitously expressed.
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數(shù)據(jù)庫(kù)鏈接：
