HMBOX1 Antibody
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中文名稱：HMBOX1兔多克隆抗體
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貨號：CSB-PA010523GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：HMBOX1
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別名：HMBOX1 antibody; HOT1 antibody; TAH1 antibody; Homeobox-containing protein 1 antibody; Homeobox telomere-binding protein 1 antibody; Telomere-associated homeobox-containing protein 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human HMBOX1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
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基因功能參考文獻：
- Low HMBOX1 expression is associated with liver cancer progression. PMID: 30015890
- HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis. PMID: 29709478
- HMBOX1 may be a potential diagnostic marker in glioma. PMID: 28731165
- Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells. PMID: 28628186
- HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells. PMID: 26456220
- a homeobox-containing protein known as HMBOX1 can directly bind telomeric double-stranded DNA and associate with PML nuclear bodies. PMID: 23813958
- HOT1 supports telomerase-dependent telomere elongation. PMID: 23685356
- our results revealed a novel regulatory mechanism: miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells by targeting HMBOX1. PMID: 22320217
- HMBOX1 may function as a negative regulator of IFN-gamma in NK cells. PMID: 21839858
- HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. PMID: 21706044
- higher HMGB1(homeobox containing 1) levels in Tracheal aspirates are associated with the development of bronchopulmonary dysplasia or death in ventilated premature infants. PMID: 20182437
- These findings suggest a distinct role of HMBOX1b, and the control of mRNA splicing might be involved in homeobox genes regulation. PMID: 19757162
- decreased expression in hepatic carcinoma PMID: 19728927
- Hmbox1 is widely expressed in pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus PMID: 16825764
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亞細胞定位：Nucleus. Cytoplasm. Chromosome, telomere. Nucleus, Cajal body. Nucleus, PML body.; [Isoform 5]: Nucleus. Cytoplasm.
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組織特異性：Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, colon, lung, cardiac muscle and thyroid gland.
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數據庫鏈接：
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