HERC5 Antibody, HRP conjugated
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中文名稱：HERC5兔多克隆抗體, HRP偶聯
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貨號：CSB-PA883435LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HERC5 Polyclonal antibody
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Uniprot No.：
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基因名：HERC5
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別名：CEB1 antibody; CEBP1 antibody; Cyclin E binding protein 1 antibody; Cyclin-E-binding protein 1 antibody; E3 ISG15--protein ligase HERC5 antibody; HECT domain and RCC1 like domain containing protein 5 antibody; HECT domain and RCC1-like domain-containing protein 5 antibody; Hect domain and RLD 5 antibody; HECT E3 ubiquitin ligase antibody; HERC5 antibody; HERC5_HUMAN antibody; Herc6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
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基因功能參考文獻：
- Low HERC5 expression is associated with HIV infections. PMID: 29669830
- A synonymous mutation at rs6857425 (T-C) was present in the same region among all study groups (T-C), irrespective of their HIV status. PMID: 28737979
- Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin. PMID: 27534820
- HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and survival in patients. PMID: 26653219
- The inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to substrates by HERC5. PMID: 26361997
- vIRF1 association with HERC5 altered ISG15 modification of cellular proteins, and knockdown of ISG15 augmented reactivation of KSHV from latency. PMID: 26355087
- The study reports on the NMR solution structure of a G-quadruplex formed by the CEB1 DNA G-rich fragment d(AGGGGGGAGGGAGGGTGG), harboring several G-tracts including one with six continuous guanines. PMID: 24742225
- Results show that HERC5 gene may be involved in regulating the spread of non-small cell lung cancer tumors where the methylation of its promoter is correlated with number increase of disseminated tumor cells and metastases as well as survival decreased. PMID: 25353388
- Authors identified a second distinct mechanism by which HERC5 inhibits HIV-1 replication and demonstrate that HERC5 is evolving under strong positive selection. PMID: 24693865
- Data indicate that income was inversely related to smoking behavior, and paternally derived CEB1 mutations were dose dependently increased when the father smoked in the 6 mo before pregnancy, 0.21 vs. 0.05 in smoking and nonsmoking fathers, respectively. PMID: 23538710
- The E3 ligase activity of HERC5 was required for blocking HIV-1 Gag particle production and correlated with the post-translational modification of Gag with ISG15. PMID: 22093708
- This study characterizes HERC5 as a positive regulator of innate antiviral responses, and show that it sustains IRF3 activation via a novel posttranslational modification, ISG15-ylation. PMID: 20308324
- Data show that HERC5, a functionally active HECT ubiquitin ligase, exhibits a tightly controlled cytosolic level under inflammatory conditions in endothelial cells. PMID: 15331633
- HERC5/Ceb1 is involved in the conjugation of ISG15 to cellular proteins. PMID: 16815975
- these results suggest that Herc5 functions as a general E3 ligase for protein ISGylation. PMID: 16884686
- Overexpression of cyclin E is associated with neuroendocrine lung tumors PMID: 17471231
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亞細胞定位：Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit.
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組織特異性：Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
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