HAX1 Antibody

說明書

中文名稱：

HAX1兔多克隆抗體
貨號(hào)：

CSB-PA010146GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

O00165
基因名：

HAX1
別名：

FLJ17042 antibody; FLJ18492 antibody; FLJ93803 antibody; HAX 1 antibody; HAX-1 antibody; HAX1 antibody; HAX1_HUMAN antibody; Hax1a antibody; HCLS1 and PKD2 associated protein antibody; HCLS1 associated protein antibody; HCLS1 associated protein X 1 antibody; HCLS1-associated protein X-1 antibody; HCLSBP1 antibody; HS 1 associated protein X 1 antibody; HS 1 binding protein antibody; HS1 associating protein X 1 antibody; HS1 binding protein 1 antibody; HS1 binding protein antibody; HS1-associating protein X-1 antibody; HS1-binding protein 1 antibody; HS1BP1 antibody; HSP1BP-1 antibody; OTTHUMP00000034190 antibody; SCN3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human HAX1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
基因功能參考文獻(xiàn)：
1. data suggest that HAX-1 may be a promoting factor for AIV H9N2 replication through desensitizing PB1-F2 from its apoptotic induction in human lung epithelial cells. PMID: 29576744
2. the HAX1 gene is important for ovarian development, in which a p.Trp44X mutation may cause primary ovarian insufficiency in female patients PMID: 28681255
3. The overexpression of HAX-1 might contribute to the malignant progression of glioma. PMID: 28751207
4. Autophagy induction is involved in HAX1-induced cell protective mechanism, and AA127-180 serves as the functional autophagy-regulatory domain of this antiapoptotic protein. PMID: 29461873
5. HAX1 is a potential oncogene, and may promote the tumorigenesis and progression of hypopharyngeal carcinoma. PMID: 28791389
6. Oncogenic HAX-1 increases the proliferation, migration, and angiogenic activity of HUVECs. Findings provide unique insight into the pathogenesis of NPC. PMID: 26871467
7. Results show that Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1. PMID: 26869103
8. results suggest that miR-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1 PMID: 27618431
9. The authors describe the first case series of patients with CN caused by HAX1 mutation who presented with HLH. They hypothesize that severe neutropenia persists after an HLH episode in children without FHLH mutations (especially infants) because these patients have CN caused by HAX1 mutations. PMID: 28169428
10. Study indicates that the overexpression of HAX-1 is essential in the development of chemoresistance in breast cancer. PMID: 28347249
11. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 inactivation. PMID: 26323553
12. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation. PMID: 26339377
13. HAX1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki67 and phosphorylatedakt were inhibited following HAX1 knockdown. PMID: 26062578
14. HAX-1 was significantly elevated in laryngeal carcinoma. PMID: 25554539
15. Authors showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger domain. PMID: 25275296
16. HAX-1 is involved in mRNA processing as an element of P-body interaction network. PMID: 25289648
17. HAX1 mutation is associated with severe congenital neutropenia. PMID: 25284454
18. HAX1 is a proto-oncogene in mantle cell lymphoma. PMID: 25419709
19. anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells PMID: 24910348
20. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. PMID: 23975175
21. A new homozygous HAX1 deletion (exons 2-5) was found in a French Kostmann syndrome pedigree. A homozygous frameshift mutation was found in exon 3 (c.430dupG, p.Val144fs) in a 2d pedigree. Neurological retardation associated with B isoform mutations. PMID: 24482108
22. HAX-1 might be an important marker for tumor progression and prognosis, as well as a potential therapeutic target of Colorectal cancer PMID: 24057929
23. Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization. PMID: 24347163
24. Studies indicate that mutations in the gene encoding HAX1 were present in patients with the autosomal recessive form of severe congenital neutropenia. PMID: 24341138
25. Hax1 physically interacts with TPC1/2 C-terminal domain. PMID: 24188827
26. 4 ELANE mutations, 11 HAX1 mutations and 2 G6PC3 mutations have been identified in Iranian patients with severe congenital neutropenia. PMID: 23454784
27. HAX-1 mRNA is over-expressed in esophageal squamous cell carcinoma and is prognostic factor for lymphatic metastasis and survival. PMID: 23531395
28. HAX-1 may be involved in the regulation of expression of bound transcripts, possibly as part of the stress response. PMID: 23164465
29. These data show that HAX1 specifically interacts with influenza A virus polymerase PA in vitro and in vivo and that HAX1 interacts with the nuclear localization signal domain of PA. PMID: 23055567
30. Hax-1 is a short-lived protein and that its PEST sequence dependent fast degradation by the proteasome. PMID: 22827267
31. We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells. PMID: 22570112
32. HAX-1 promotes the proliferation, chemoresistance, invasion, and tumorigenicity of esophageal squamous cell carcinoma. PMID: 22451114
33. Data suggest that Hax-1 is a new PrP-interacting partner that may play role in cell oxidative stress and anti-apoptosis physiologically and cell damage pathologically. PMID: 21301993
34. hSav1 interacts with HAX1 and attenuates its protective role against apoptosis in MCF-7 breast cancer cells. PMID: 21567072
35. Novel HAX1 gene mutations are associated with neurodevelopmental abnormalities in two Italian patients with severe congenital neutropenia. PMID: 20065084
36. Hax1 is a novel regulator of neutrophil uropod detachment and chemotaxis through RhoA PMID: 21518791
37. Our resultsvindicate that HAX-1 may not be a candidate gene for psoriasis susceptibility in the Chinese Han population. PMID: 21109726
38. Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated. PMID: 20665473
39. Biallelic mutations in the antiapoptotic gene HAX1 were identified in patients with autosomal recessive severe congenital neutropenia. PMID: 21206270
40. identified consanguineous family with 2 patients with severe congenital neutropenia and neurological disease caused by novel, homozygous genomic deletion including exons 4-7 of the HAX1 gene; quantitative MRI showed alteration in cerebral proton density PMID: 21108402
41. analysis of HAX-1 overexpression, splicing and cellular localization in tumors PMID: 20196840
42. HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells PMID: 19913549
43. The N(pro)-HAX-1 interaction was confirmed using co-precipitation assays. PMID: 20631090
44. describe congenital neutropenia patients with mutations in two candidate genes each,HAX1 and G6PC3, including 6 novel mutations PMID: 20220065
45. This study is the first to demonstrate GrB activity within the mitochondrion and to identify Hax-1 cleavage as a novel mechanism for GrB-mediated mitochondrial depolarization. PMID: 20388708
46. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
47. HAX-1 suppresses the polyubiquitination of XIAP; formation of the HAX-1-XIAP complex inhibits apoptosis by enhancing the stability of XIAP against proteosomal degradation. PMID: 20171186
48. study suggests that the novel missense c.421T>C mutation in the HAX1 gene produces a milder form of severe congenital neutropenia without apparent developmental or neurological manifestations PMID: 19796188
49. Interacts with the alpha subunit of G protein G13 to promote cell migration. PMID: 15339924
50. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing. PMID: 19680265
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相關(guān)疾病：

Neutropenia, severe congenital 3, autosomal recessive (SCN3)
亞細(xì)胞定位：

Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 5]: Cytoplasm.
蛋白家族：

HAX1 family
組織特異性：

Ubiquitous. Up-regulated in oral cancers.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16915

OMIM: 605998

KEGG: hsa:10456

STRING: 9606.ENSP00000329002

UniGene: Hs.199625

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