Gpi Antibody

中文名稱：

Gpi兔多克隆抗體
貨號：

CSB-PA009717LA01MO
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Gpi Polyclonal antibody
Uniprot No.：

P06745
基因名：

Gpi
別名：

Gpi antibody; Gpi1Glucose-6-phosphate isomerase antibody; GPI antibody; EC 5.3.1.9 antibody; Autocrine motility factor antibody; AMF antibody; Neuroleukin antibody; NLK antibody; Phosphoglucose isomerase antibody; PGI antibody; Phosphohexose isomerase antibody; PHI antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Glucose-6-phosphate isomerase protein (2-558AA)
免疫原種屬：

Mus musculus (Mouse)

標記方式：

Non-conjugated

本頁面中的產品，Gpi Antibody (CSB-PA009717LA01MO)，的標記方式是Non-conjugated。對于Gpi Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009717LB01MO	Gpi Antibody, HRP conjugated	ELISA
FITC	CSB-PA009717LC01MO	Gpi Antibody, FITC conjugated
Biotin	CSB-PA009717LD01MO	Gpi Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
基因功能參考文獻：
1. PGI is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor. PMID: 8674049
2. The mGPI-transgenic mice presented GPI more efficiently and showed a dramatic increase in negative selection and an inhibition of arthritis. PMID: 23840022
3. Data show that silencing of AMF/PGI induced MET and suppressed the tumor growth and pulmonary metastasis of LM8 cells in nude mice. PMID: 20978190
4. induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid (tumor autocrine motility factor) PMID: 12054583
5. acid-induced conformational changes in phosphoglucose isomerase result in its increased cell surface association and deposition on fibronectin fibrils PMID: 12888574
6. Gpi1 immunoreactivity was found in ganglion, amacrine, horizontal and bipolar cells, but not in rods, cones, pigment epithelium and Muller cells. PMID: 15182299
7. High-resolution crystal structures of the enzyme from mouse have been determined in native form and in complex with the inhibitor erythrose 4-phosphate, and with the substrate glucose 6-phosphate. PMID: 15342241
8. crystal structure of Autocrine Motility Factor PMID: 15502335
9. AMF expression significantly contributes to the aggressive phenotype of pancreatic cancer PMID: 15570012
10. Results report the first high-resolution crystal structure of the inhibitor-free form and the eight types of inhibitor complexes of mouse autocrine motility factor. PMID: 16375918
11. the receptor molecule for AMF/NLK/MF in leukemic differentiation is not gp78 PMID: 17071500
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亞細胞定位：

Cytoplasm. Secreted.
蛋白家族：

GPI family
數據庫鏈接：

KEGG: mmu:14751

STRING: 10090.ENSMUSP00000049355

UniGene: Mm.589

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