GZMM Antibody, Biotin conjugated

說明書

中文名稱：

GZMM兔多克隆抗體, Biotin偶聯(lián)
貨號(hào)：

CSB-PA010085LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GZMM Polyclonal antibody
Uniprot No.：

P51124
基因名：

GZMM
別名：

GRAM_HUMAN antibody; Granzyme M (lymphocyte met ase 1) antibody; Granzyme M antibody; GranzymeM antibody; GZM M antibody; Gzmm antibody; HU Met 1 antibody; HU-Met-1 antibody; LMET 1 antibody; LMET1 antibody; Lymphocyte met ase 1 antibody; MET 1 antibody; Met 1 serine protease antibody; Met ase antibody; Met-1 serine protease antibody; Met-ase antibody; MET1 antibody; Met1 serine protease antibody; Natural killer cell granular protease antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Granzyme M protein (98-243AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
基因功能參考文獻(xiàn)：
1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced. PMID: 27441655
2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain. PMID: 27133719
3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients. PMID: 24316590
4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. PMID: 23099853
5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. PMID: 21979465
6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
7. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes. PMID: 20107908
8. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. PMID: 21059895
9. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells PMID: 20406824
10. These findings support not only a role for GrM in the innate but also in the adaptive immune response. PMID: 19896187
11. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity. PMID: 12506019
12. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells PMID: 15028722
13. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis. PMID: 16818775
14. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death. PMID: 18523284
15. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. PMID: 19103589
16. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. PMID: 19542453
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亞細(xì)胞定位：

Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
蛋白家族：

Peptidase S1 family, Granzyme subfamily
組織特異性：

Highly and constitutively expressed in activated natural killer (NK) cells.
數(shù)據(jù)庫鏈接：

HGNC: 4712

OMIM: 600311

KEGG: hsa:3004

STRING: 9606.ENSP00000264553

UniGene: Hs.465511

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