GZMK Antibody

中文名稱：

GZMK兔多克隆抗體
貨號：

CSB-PA010084LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA010084LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA010084LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA010084LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GZMK Polyclonal antibody
Uniprot No.：

P49863
基因名：

GZMK
別名：

Fragmentin 3 antibody; Fragmentin-3 antibody; Fragmentin3 antibody; GRAK_HUMAN antibody; Granzyme 3 antibody; granzyme K (granzyme 3; tryptase II) antibody; granzyme K (serine protease; granzyme 3; tryptase II) antibody; Granzyme K antibody; Granzyme K precursor antibody; Granzyme-3 antibody; Granzyme3 antibody; GranzymeK antibody; GZMK antibody; NK TRYP 2 antibody; NK TRYP2 antibody; NK tryptase 2 antibody; NK-TRYP-2 antibody; NK-tryptase-2 antibody; NKTRYP2 antibody; Serine protease granzyme 3 antibody; TRYP 2 antibody; TRYP2 antibody; Tryptase II antibody; TryptaseII antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Granzyme K protein (27-264AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GZMK Antibody (CSB-PA010084LA01HU)，的標記方式是Non-conjugated。對于GZMK Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA010084LB01HU	GZMK Antibody, HRP conjugated	ELISA
FITC	CSB-PA010084LC01HU	GZMK Antibody, FITC conjugated
Biotin	CSB-PA010084LD01HU	GZMK Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. PMID: 26936634
2. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response. PMID: 24711407
3. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells. PMID: 21666061
4. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. PMID: 20377743
5. The 2.2-A crystal structure reveals a rigid zymogen with unusual features PMID: 12384499
6. The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart. PMID: 12387726
7. We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks. PMID: 17008916
8. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. PMID: 17438453
9. p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. PMID: 19201868
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亞細胞定位：

Secreted. Cytoplasmic granule.
蛋白家族：

Peptidase S1 family, Granzyme subfamily
組織特異性：

Expressed in lung, spleen, thymus and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 4711

OMIM: 600784

KEGG: hsa:3003

STRING: 9606.ENSP00000231009

UniGene: Hs.277937

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