GRM7 Antibody

說明書

中文名稱：

GRM7兔多克隆抗體
貨號：

CSB-PA962170
規格：

￥2024
圖片：
Western blot analysis of extracts from HuvEc cells, using GluR7 antibody.

Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR7 antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GRM7 Polyclonal antibody
Uniprot No.：

Q14831
基因名：

GRM7
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human GluR7.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
基因功能參考文獻：
1. The mutant allele C in rs1485175 of the GMR7 may decrease individuals' susceptibility to noise-induced hearing loss. PMID: 29301492
2. The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population. PMID: 28027116
3. study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample PMID: 27788777
4. Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway. PMID: 27312574
5. GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia. PMID: 26856250
6. Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits. PMID: 26866891
7. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population PMID: 26655190
8. Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
9. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population. PMID: 26254163
10. results reported here do not support a role for GRM7 in ADHD PMID: 25360607
11. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder. PMID: 24804643
12. For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4, we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS PMID: 24278217
13. in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns. PMID: 24146964
14. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population PMID: 23295062
15. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults. PMID: 23102807
16. SNPs in autism spectrum disorders PMID: 23201551
17. Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population. PMID: 20078931
18. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication. PMID: 21572164
19. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). PMID: 21572167
20. Data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain. PMID: 21813496
21. we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons PMID: 21255632
22. As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in age-related hearing impairment, this study provides further evidence for the involvement of this gene. PMID: 20068591
23. Identified additional splicing variants involving the 3' end of the GRM7 coding sequence and resulting in three putative novel isoforms. PMID: 12052533
24. The results of this study support the possible association of a GRM7 gene polymorphism with genetic susceptibility to schizophrenia. PMID: 18329248
25. GRM7 contributes to risk of developing age-related hearing impairment. PMID: 19047183
26. Study results provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. PMID: 19638256
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 3 family
組織特異性：

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
數據庫鏈接：

HGNC: 4599

OMIM: 604101

KEGG: hsa:2917

STRING: 9606.ENSP00000350348

UniGene: Hs.606393

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