GRIN3B Antibody

說明書

中文名稱：

GRIN3B兔多克隆抗體
貨號：

CSB-PA009917ESR1HU
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GRIN3B Polyclonal antibody
Uniprot No.：

O60391
基因名：

GRIN3B
別名：

GluN3B antibody; Glutamate [NMDA] receptor subunit 3B antibody; Glutamate receptor ionotropic N methyl D aspartate 3B antibody; Glutamate receptor ionotropic NMDA 3B antibody; GRIN3B antibody; N-methyl-D-aspartate receptor subtype 3B antibody; NMD3B_HUMAN antibody; NMDA receptor subunit 3B antibody; NMDA type glutamate receptor subunit NR3B antibody; NMDAR3B antibody; NR3B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Glutamate receptor ionotropic, NMDA 3B protein (180-410AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
基因功能參考文獻：
1. GRIN3B missense mutation is an inherited risk factor for schizophrenia. PMID: 28132660
2. Authors investigated the significance of a common human genetic variation of the NMDAR NR3B subunit PMID: 25768306
3. Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects. PMID: 24814139
4. our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse. PMID: 20153313
5. These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
6. NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions. PMID: 15722182
7. cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors PMID: 17543277
8. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). PMID: 17687115
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
數據庫鏈接：

HGNC: 16768

OMIM: 606651

KEGG: hsa:116444

STRING: 9606.ENSP00000234389

UniGene: Hs.660378

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