GRID2 Antibody
-
中文名稱：GRID2兔多克隆抗體
-
貨號：CSB-PA008961
-
規格：￥1090
-
圖片：
-
Western Blot analysis of 3T3 cells using GluR-δ2 Polyclonal Antibody
-
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：GRID2
-
別名：delta-2 antibody; GluD2 antibody; GLUR D2 antibody; GluR delta 2 antibody; GluR delta-2 subunit antibody; GLURD 2 antibody; GLURD2 antibody; Glutamate receptor delta 2 subunit antibody; Glutamate receptor ionotropic antibody; Glutamate receptor ionotropic delta 2 antibody; GRID 2 antibody; Grid2 antibody; GRID2_HUMAN antibody; MGC117022 antibody; MGC117023 antibody; MGC117024 antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse,Rat
-
免疫原：Synthesized peptide derived from the C-terminal region of Human GluR-δ2.
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產品提供形式：Liquid
-
應用范圍：WB, IF, ELISA
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
-
基因功能參考文獻：
- Report on a consanguineous family with autosomal recessive childhood onset of cerebellar ataxia and delayed psychomotor development. Using whole exome sequencing we identified a novel homozygous missense variant [c.2128C > T, p.(Arg710Trp)] in GRID2 that segregates with the disease. The missense variant is located in a conserved region encoding the extracellular serine-binding domain of the GluD2 protein. PMID: 29207948
- GRID2 gene can be a suppressor in TNF-induced neurodegeneration which may help to understand the main factors leading to autism. PMID: 27019035
- Glutamate system genes including have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
- findings suggest a possible role of GRID2 in the susceptibility to develop mevalonate kinase deficiency. GRID2 gene associated with MKD: The rs1450500 SNP was differently distributed in patients with MKD with respect to those with recurrent fever. PMID: 25146332
- We demonstrated for the first time GRID2 expression and localization in human and murine retina, providing evidence for a novel functional role of GRID2 in the retina. PMID: 25122145
- GRID2 point mutations: cerebellar ataxia is the core phenotype, but with variable severity ranging from very mild adult-onset to congenital-onset linked to both the heterozygous and homozygous state of the variant, and the position of the mutation. PMID: 25841024
- GluD2 gating is triggered by type 1 metabotropic glutamate receptors. PMID: 24357660
- GRID2 mutations are associated with a recessive syndrome causing cerebellar ataxia and eye movement abnormalities. PMID: 24078737
- Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers PMID: 23512105
- Glutamate receptor delta2 is involved in a common mechanism that restricts the number of synaptic AMPA receptors at parallel fiber synapses in cerebellar Purkinje cells. PMID: 21368048
- Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin. PMID: 17027646
- The carboxy terminus of transgenic GluRdelta2 conveys the signal(s) necessary for long-term depression induction and motor learning. PMID: 18256267
顯示更多
收起更多
-
相關疾病：Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18)
-
亞細胞定位：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
-
蛋白家族：Glutamate-gated ion channel (TC 1.A.10.1) family, GRID2 subfamily
-
數據庫鏈接：
