GRAMD4 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GRAMD4 Polyclonal antibody
Uniprot No.：

Q6IC98
基因名：

GRAMD4
別名：

GRAMD4; DIP; KIAA0767; GRAM domain-containing protein 4; Death-inducing protein
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GRAM domain-containing protein 4 protein (23-161AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response.
基因功能參考文獻：
1. The expression of GRAMD4 is up-regulated in hepatocellular carcinoma cell(HCC cell) lines and HCC tissues, and the increased expression is correlated with the clinicopathological characteristics of HCC. PMID: 23388340
2. GRAMD4 induces changes in Bcl-2 and Bax protein levels PMID: 21127500
3. localizes to the mitochondria, upregulated following E2F1 induction PMID: 15565177
4. DIP induces p53-independent caspase-dependent and -independent apoptosis. DIP is localized in the mitochondria. DIP accumulates upon E2F1 activation. PMID: 15565177
亞細胞定位：

Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
數據庫鏈接：

HGNC: 29113

OMIM: 613691

KEGG: hsa:23151

STRING: 9606.ENSP00000354313

UniGene: Hs.475150

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