GPAA1 Antibody

說(shuō)明書

產(chǎn)品詳情

Uniprot No.：

O43292
基因名：

GPAA1
別名：

GPAA1; GAA1; Glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human GPAA1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
基因功能參考文獻(xiàn)：
1. The splicing mutation was found to decrease GPAA1 mRNA. PMID: 29100095
2. the lumenal domain of GAA1/GPAA1 has a 3D structure similar to that of an M28-type aminopeptidase. GAA1/GPAA1 is a candidate for the enzyme that catalyzes the peptide bond formation between the omega-site and a phosphoethanolamine group of GPI lipid anchor. PMID: 24743167
3. a conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol recognition by GPI transamidase PMID: 14660601
4. passively retained in the ER by a signalless mechanism PMID: 15713669
5. Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 is associated with gene amplification in hepatocellular carcinoma PMID: 16642471
6. Results show an increased expression level and elevated copy number for GAA1 in head and neck squamous carcinoma, suggesting a role for this GPI anchor subunit in HNSCC. PMID: 18028549
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亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4446

OMIM: 603048

KEGG: hsa:8733

STRING: 9606.ENSP00000347206

UniGene: Hs.627962

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