GOT2 Antibody, HRP conjugated

說明書

中文名稱：

GOT2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA03065B0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GOT2 Polyclonal antibody
Uniprot No.：

P00505
基因名：

GOT2
別名：

AATM_HUMAN antibody; AL022787 antibody; Aspartate aminotransferase 2 antibody; Aspartate aminotransferase antibody; Aspartate aminotransferase; mitochondrial antibody; Aspartate transaminase 2 antibody; ASPATA antibody; EC 2.6.1.1 antibody; FABP 1 antibody; FABP pm antibody; FABP-1 antibody; FABPpm antibody; Fatty acid binding protein antibody; Fatty acid-binding protein antibody; FLJ40994 antibody; Glutamate oxaloacetate transaminase 2 antibody; Glutamate oxaloacetate transaminase 2; mitochondrial antibody; Glutamate oxaloacetate transaminase; mitochondrial antibody; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) antibody; Got 2 antibody; GOT2 antibody; KAT4 antibody; KATIV antibody; kynurenine aminotransferase 4 antibody; Kynurenine aminotransferase IV antibody; kynurenine--oxoglutarate transaminase 4 antibody; kynurenine--oxoglutarate transaminase IV antibody; mAspAT antibody; MGC102129 antibody; MGC115763 antibody; mitAAT antibody; mitochondrial antibody; Mitochondrial aspartate aminotransferase antibody; OTTMUSP00000017748 antibody; Plasma membrane fatty acid binding protein antibody; Plasma membrane-associated fatty acid-binding protein antibody; Transaminase A antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Aspartate aminotransferase, mitochondrial protein (33-279AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
基因功能參考文獻：
1. Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
2. The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
3. Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
4. Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
5. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
6. High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
7. The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
8. Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674
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亞細胞定位：

Mitochondrion matrix. Cell membrane.
蛋白家族：

Class-I pyridoxal-phosphate-dependent aminotransferase family
數據庫鏈接：

HGNC: 4433

OMIM: 138150

KEGG: hsa:2806

STRING: 9606.ENSP00000245206

UniGene: Hs.599470

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