GNRH1 Antibody

說明書

中文名稱：

GNRH1兔多克隆抗體
貨號：

CSB-PA008890
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P01148
基因名：

GNRH1
別名：

GNRH1 antibody; GNRH antibody; GRH antibody; LHRHProgonadoliberin-1 antibody; Progonadoliberin I) [Cleaved into: Gonadoliberin-1 antibody; Gonadoliberin I antibody; Gonadorelin antibody; Gonadotropin-releasing hormone I antibody; GnRH-I antibody; Luliberin I antibody; Luteinizing hormone-releasing hormone I antibody; LH-RH I); GnRH-associated peptide 1 antibody; GnRH-associated peptide I)] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human GnRH I.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
基因功能參考文獻：
1. High expression of LHRH is associated with ovarian cancer. PMID: 27793127
2. GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites. PMID: 26920257
3. High LHRH expression is associated with sarcomas of bone and soft tissue. PMID: 27639272
4. mutations in the region encoding the decapeptide associated with complete Idiopathic hypogonadotropic hypogonadism PMID: 26595427
5. GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression. PMID: 26660506
6. analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells PMID: 26644469
7. our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy. PMID: 25955300
8. Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review) PMID: 25916694
9. Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG. PMID: 26308290
10. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes PMID: 24002956
11. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
12. Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist. PMID: 24603682
13. GnRH agonists fail to increase Bax expression and do not potentiate the cytotoxic activity of docetaxel PMID: 24722580
14. GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma. PMID: 24472523
15. This review will summarize the current understanding of the mechanisms by which PACAP modulates gonadotrope function, with a focus on interactions with GnRH. PMID: 24095645
16. Current research efforts aim to discover the mechanisms responsible for the decoding of the GnRH pulse signal by the gonadotrope. PMID: 24056171
17. GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells. PMID: 24264576
18. This review summarizes the mechanisms used by glial cells to control GnRH neuronal ativity and secretion. PMID: 23735672
19. R31C GNRH1 is the only missense mutation that was identified in a CpG islet in nine congenital hypogonadotropic hypogonadism subjects from four unrelated families, giving evidence for a putative ''hot spot''. PMID: 23936060
20. GnRHI, GnRHII and GnRH receptor expression correlated significantly with poor prognosis in breast cancer patients PMID: 23287110
21. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. PMID: 23648337
22. Olfactory ensheathing cells form a microenvironment for migrating GnRH-1 neurons during development. PMID: 23404564
23. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome PMID: 24010162
24. Kisspeptin and GnRH pulse generation. PMID: 23550012
25. Kisspeptin resets the GnRH pulse generator in men, but does not appear to do so in women PMID: 23550003
26. Spontaneous GnRH release is detected in the median eminence of transgenic mice that produce diurnal variations in GnRH. PMID: 23077052
27. The role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression in this REVIEW. PMID: 22161498
28. data demonstrate that GnRH transcription is repressed by AR via multiple sequences in GnRH-P, including three Oct-1 binding sites, and that this repression requires the complex interaction of several transcription factors PMID: 22074952
29. molecular mechanisms involved in GnRH/GnRHR signaling at the maternal-fetal interface. [Review] PMID: 22024993
30. Mutations in GNRH1 have been associated with both mild and severe forms of GnRH deficiency, and may work in combination with other gene mutations to produce GnRH-deficient phenotypes. PMID: 21722705
31. [review] Existing evidence suggests that neural pathways originating in hindbrain and hypothalamic feeding nuclei transmit information concerning glucose availability to GnRH neurons, which integrate numerous physiological signals and metabolic cues. PMID: 21855365
32. Data show that higher levels of GnRH IgM antibodies were detected in patients with IBS and dysmotility, but not organic GI diseases, compared with healthy controls. PMID: 21714833
33. Assessment of CGB and GNRH1 expression level in cancer patients' blood may be useful for indicating metastatic spread of tumor cells. PMID: 21827674
34. Sleep is associated with a significant decline in GnRH pulse frequency in both older and younger postmenopausal women PMID: 21646369
35. Deletion of the cell-specific enhancer region of GnRH implicates the GnRH promoter in mediating pubertal development and periodic reproductive cycling. PMID: 21368045
36. Lactation is an important physiological model of the integration of energy balance and reproduction, as it involves activation of potent appetitive neuropeptide systems coupled to a profound inhibition of pulsatile GnRH/LH secretion--REVIEW PMID: 20727862
37. A large literature dealing with various stressors that regulate gonadotrophin-releasing hormone secretion in a variety of species provides evidence that stress modulates GnRH secretion by activating the corticotrophin-releasing factor system--REVIEW PMID: 20727865
38. The sources of glutamatergic inputs to the GnRH neurons are only just beginning to be examined and include the anteroventral periventricular nucleus as well as the possibility that GnRH neurons--REVIEW PMID: 20807514
39. We then discuss possible neurobiological mechanisms underlying GnRH pulse generation, and conclude by proposing that kisspeptin neurons in the arcuate nucleus are key players--REVIEW PMID: 20951683
40. homozygous inactivating mutations in the GNRH1 gene causing hypothalamic hypogonadotropic hypogonadism in patients were reported, validating definitively the pivotal role of GnRH in human pubertal development and reproduction--REVIEW PMID: 20887715
41. GNRH1 mutations might cause congenital idiopathic (or isolated) hypogonadotropic hypogonadism (Review) PMID: 20389089
42. The role of GnRH-GnRHR signaling at the maternal-fetal interface therefore appears to be limited to the regulation of trophoblast hCG production. PMID: 20400076
43. Data describe the distribution and sex dimorphism of kisspeptin-immunoreactive elements in hypothalami, reveal contacts between kisspeptin-immunoreactive fibers and GnRH cells, and colocalize kisspeptins and neurokinin B in the infundibular nucleus. PMID: 20529119
44. Metabolic signals are integrated at the levels of first-order neurons equipped with the proper receptors, ant that these neurons send their signals towards hypothalamic GnRH neurons which constitute the integrative element of this network. PMID: 20138117
45. The major genes associated with GnRH-dependent pubertal disorders, are reviewed. PMID: 20188792
46. Review: Using human GnRH deficiency as a paradigm and presenting original data from the screening of numerous candidate genes, we discuss the emerging model of patient-focused clinical genetic research. PMID: 20484732
47. cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer. PMID: 20118984
48. data indicate that the promoter region between -992 and -795 contains elements both essential and sufficient for targeting gene expression to GnRH neurons PMID: 11875100
49. Coupling of GnRH concentration and the GnRH receptor-activated gene program PMID: 12040003
50. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH. PMID: 12054733
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相關疾病：

Hypogonadotropic hypogonadism 12 with or without anosmia (HH12)
亞細胞定位：

Secreted.
蛋白家族：

GnRH family
數據庫鏈接：

HGNC: 4419

OMIM: 152760

KEGG: hsa:2796

STRING: 9606.ENSP00000276414

UniGene: Hs.82963

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