GNMT Antibody
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中文名稱：GNMT兔多克隆抗體
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貨號：CSB-PA931421
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規格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA931421(GNMT Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：GNMT
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別名：EC 2.1.1.20 antibody; Epididymis secretory sperm binding protein Li 182mP antibody; Glycine N methyltransferase antibody; Glycine N-methyltransferase antibody; Gnmt antibody; GNMT_HUMAN antibody; HEL S 182mP antibody; OTTHUMP00000016412 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human GNMT
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
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基因功能參考文獻：
- Elevated GNMT protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
- In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk. PMID: 24800880
- GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon. PMID: 23883094
- The studies identify GNMT as a direct transcriptional target of the AR. PMID: 23997240
- DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC), and loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters PMID: 23475283
- single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer PMID: 22850906
- Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
- GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior. PMID: 22264868
- GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis. PMID: 22415010
- In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway PMID: 22160218
- GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer PMID: 21572396
- This study suggests that the glycine N-methyltransferase STRP1 phenotype could modulate urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels in coke-oven workers exposed to PAHs. PMID: 21691217
- investigation of role of GNMT in methyl group homeostasis in liver: GNMT affects transmethylation kinetics, SAM synthesis, and conservation of methyl groups by limiting homocysteine remethylation flux; possible role of GNMT inactivation in hepatoma PMID: 21411609
- compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease PMID: 11810299
- Results suggest that GNMT alteration may be an early event in hepatocellular carcinoma development and that GNMT could be a new tumor susceptibility gene for hepatocellular carcinoma. PMID: 12566309
- GNMT 1289 C-->T polymorphism influences plasma homocysteine and is responsive to folate intake. PMID: 16317120
- GNMT is destabilized by a mutation. PMID: 17660255
- Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. PMID: 18624901
- GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models PMID: 19035462
- A transgenic mouse model is used together with in vitro methods to study the ability of the GNMT transgene to block the cytotoxic or carcinogenic activity of aflatoxin B1, a known causal agent of human hepatocellular carcinoma. PMID: 19146867
- Study identified a GNMT transcriptional start site at the 14th position upstream of the ATG codon; results indicate binding of the nuclear factor-Y (NF-Y) transcription factor to the CCAAT box (-71/-67) of the GNMT gene. PMID: 19439180
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相關疾病：Glycine N-methyltransferase deficiency (GNMT deficiency)
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亞細胞定位：Cytoplasm.
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蛋白家族：Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
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組織特異性：Abundant in liver.
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數據庫鏈接：
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