GNB4 Antibody

說明書

中文名稱：

GNB4兔多克隆抗體
貨號：

CSB-PA009607GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HAV0
基因名：

GNB4
別名：

G protein beta 4 subunit antibody; GBB4_HUMAN antibody; GNB 4 antibody; Gnb4 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 4 antibody; Guanine nucleotide binding protein beta 4 subunit antibody; Guanine nucleotide binding protein beta polypeptide 4 antibody; Guanine nucleotide binding protein beta subunit 4 antibody; Guanine nucleotide binding protein subunit beta 4 antibody; Guanine nucleotide-binding protein subunit beta-4 antibody; Transducin beta chain 4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human GNB4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
基因功能參考文獻：
1. GNB4 is important for growth of breast cancer cells and a potential target for treatment PMID: 30103729
2. A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population. PMID: 28642160
3. Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling. PMID: 25916507
4. Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation. PMID: 23434117
5. Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells. PMID: 12454992
6. Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5 PMID: 12782285
7. Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer. PMID: 18815590
8. Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma. PMID: 19414374
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相關疾病：

Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
蛋白家族：

WD repeat G protein beta family
組織特異性：

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.
數據庫鏈接：

HGNC: 20731

OMIM: 610863

KEGG: hsa:59345

STRING: 9606.ENSP00000232564

UniGene: Hs.173030

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