GNAL Antibody
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中文名稱：GNAL兔多克隆抗體
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貨號：CSB-PA009592LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: Colo320 whole cell lysate
All lanes: GNAL antibody at 4.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 53, 21 kDa
Observed band size: 45 kDa -
IHC image of CSB-PA009592LA01HU diluted at 1:500 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
IHC image of CSB-PA009592LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GNAL Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Adenylate cyclase stimulating G alpha protein; olfactory type antibody; Adenylate cyclase-stimulating G alpha protein antibody; DYT25 antibody; G alpha olf antibody; Gnal antibody; GNAL_HUMAN antibody; Guanine nucleotide binding protein (G protein); alpha activating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein (G protein); alpha stimulating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein G(olf) subunit alpha antibody; Guanine nucleotide-binding protein G(olf) subunit alpha antibody; olfactory type antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Guanine nucleotide-binding protein G(olf) subunit alpha protein (4-116AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，GNAL Antibody (CSB-PA009592LA01HU)，的標(biāo)記方式是Non-conjugated。對于GNAL Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
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基因功能參考文獻(xiàn)：
- GNAL mutation may represent one of the rare causative genetic factors of isolated laryngeal dystonia. PMID: 27093447
- GNAL mutations are not a common cause of dystonia in the Brazilian population PMID: 26810727
- We report a novel GNAL mutation in Italian family with adult-onset, dominantly-inherited dystonia PMID: 26725140
- Mutations in the GNAL gene may not be a common cause of isolated dystonia in the Chinese population. PMID: 26365774
- This study demonstrated that Mutations in GNAL may cause Dystonia. PMID: 25847575
- identified two novel GNAL mutations: one heterozygous missense variant in GNAL exon 4, c.289A>G. PMID: 25382112
- The findings of this study further support GNAL as causative gene in adult-onset isolated dystonia. PMID: 24408567
- This study identified a novel likely disease-causing GNAL mutation in a Serbian patient with cervical dystonia and a classical DYT25 phenotype. PMID: 24729450
- Primary dystonia in the Amish-Mennonites is genetically diverse and includes not only the THAP1 indel founder mutation but also different mutations in THAP1 and GNAL as well as the TOR1A GAG deletion. PMID: 24500857
- GNAL variants seem to be a rare cause of primary torsion dystonia in our mainly sporadic German sample. PMID: 24151159
- Our own data suggest that GNAL mutations do not represent a common cause of dystonia in the U.K. population. PMID: 24222099
- The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). PMID: 24144882
- GNAL mutations potentially increase ethnic susceptibility to movement disorders induced by dopamine antagonists. PMID: 24535567
- Mutations in GNAL gene can cause adult-onset primary dystonia in Chinese patients PMID: 23759320
- Familial adult-onset primary dystonia can result from mutations in GNAL. PMID: 23449625
- Mutations in GNAL cause primary torsion dystonia. PMID: 23222958
- these findings provide important clues to understanding physiological functions of XLGalpha(olf). PMID: 22120635
- investigation of whether polymorphisms in the alpha subunit of the Golf gene (A-->G in intron 3, and T-->G in intron 10) are associated with major depression; additionally tested for a parent-of-origin effect in separated gender groups PMID: 11901355
- promotes cellular invasion, survival and neuroendocrine differentiation in colon, kidney and prostate epithelial cells PMID: 12037684
- No support for the hypothesis that the olfactory G-protein gene is a major susceptibility factor for bipolar disorders. PMID: 12782961
- identified a transcriptional variant of the GNAL gene in chromosome 18p11.2 in susceptibility to bipolar disorder and schizophrenia PMID: 16044173
- Galpha(olf) variant XLGalpha(olf) interacts with the human adenosine A2A receptor PMID: 16818375
- We hypothesized that the G(s)-like subunit Galpha(olf), expressed in D1-rich areas of the brain, contributes to the genetic susceptibility of ADHD. We examined the inheritance pattern of 12 GNAL polymorphisms in 258 nuclear families. PMID: 17166517
- This study provides important clues toward understanding physiological functions of XLGalpha(olf). PMID: 19245791
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相關(guān)疾病：Dystonia 25 (DYT25)
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蛋白家族：G-alpha family, G(s) subfamily
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組織特異性：Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
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