GMPR2 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GMPR2 Polyclonal antibody
Uniprot No.：

Q9P2T1
基因名：

GMPR2
別名：

GMPR2GMP reductase 2 antibody; GMPR 2 antibody; EC 1.7.1.7 antibody; Guanosine 5'-monophosphate oxidoreductase 2 antibody; Guanosine monophosphate reductase 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GMP reductase 2 protein (1-366AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GMPR2 Antibody (CSB-PA873740LA01HU)，的標記方式是Non-conjugated。對于GMPR2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA873740LB01HU	GMPR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873740LC01HU	GMPR2 Antibody, FITC conjugated
Biotin	CSB-PA873740LD01HU	GMPR2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
基因功能參考文獻：
1. Loss of expression of GMPR2 and PPARalpha is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis. PMID: 23208589
2. A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR). PMID: 22037469
3. Data suggest the existence of two distinct types of human GMP reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP reductase. PMID: 12009299
4. GMPR2 is a novel human GMP reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells. PMID: 12669231
蛋白家族：

IMPDH/GMPR family, GuaC type 1 subfamily
組織特異性：

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 4377

OMIM: 610781

KEGG: hsa:51292

STRING: 9606.ENSP00000392859

UniGene: Hs.368855

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