GAPDHS Antibody

說明書

中文名稱：

GAPDHS兔多克隆抗體
貨號：

CSB-PA009254GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O14556
基因名：

GAPDHS
別名：

G3PT_HUMAN antibody; GAPD2 antibody; GAPDH 2 antibody; GAPDH-2 antibody; GAPDH2 antibody; GAPDHS antibody; GAPDS antibody; Glyceraldehyde 3 phosphate dehydrogenase spermatogenic antibody; Glyceraldehyde 3 phosphate dehydrogenase; testis specific antibody; Glyceraldehyde-3-phosphate dehydrogenase antibody; HSD 35 antibody; HSD35 antibody; Spermatogenic cell specific glyceraldehyde 3 phosphate dehydrogenase 2 antibody; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2 antibody; Spermatogenic glyceraldehyde 3 phosphate dehydrogenase antibody; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase antibody; testis-specific antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human GAPDHS
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.
基因功能參考文獻：
1. GAPDS overexpression antagonize high glucose-induced apoptosis by controlling reactive oxygen species accumulation in TM3 cells. PMID: 29626473
2. It is assumed that the deficiency in GAPDS observed in most dysplasia of the fibrous sheath sperm samples is ascribable to a disorder in the regulation of GAPDS expression caused by the mutation in the intron region of GAPDS gene. PMID: 27135296
3. This result implies that GAPDHS participates in specific signal-transduction pathways. PMID: 26660717
4. Structural basis for the NAD binding cooperativity and catalytic characteristics of sperm-specific glyceraldehyde-3-phosphate dehydrogenase PMID: 25936797
5. GAPDS protein was expressed in both Sertoli cells and elongated sperms. The expression of GAPDS gradually increased with age in the epididymis. PMID: 23306140
6. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively. PMID: 23675907
7. the expression of GAPDS in melanoma cells may facilitate glycolysis and prevent the induction of apoptosis. PMID: 23026046
8. The chaperonin TRiC was shown to assist an ATP-dependent refolding of recombinant forms of GAPDS. PMID: 21995946
9. Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS. PMID: 21269272
10. Human his-GAPDHS expressed in baculovirus-infected insect cells is homotetrameric. PMID: 20828617
11. Data suggest that high stability of the sperm-specific GAPDS is of importance for the efficiency of fertilization. PMID: 20833277
12. We have concluded that a simple nuclear localization of GAPDH does not induce apoptosis, and that MPP+-induced apoptosis is not caused by nuclear translocation of GAPDH. PMID: 16324157
13. Comparative study of the amino acid sequences of mammalian GAPDs revealed conservative cysteine residues (C21, C94, and C150) that are specific for the sperm isoenzyme and absent in the somatic isoenzyme. PMID: 18298375
14. Characterization of the rat GAPDHS and comparison to the human and mouse enzymes. PMID: 16700075
15. GAPD2 enzymatic activity is present in human sperm. GAPD2 is tightly bound to sperm and most enzymatic activity is not released by permeabilization with CHAPS detergent. GAPD2 is restricted in location to the principal piece of the sperm flagellum. PMID: 10714828
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亞細胞定位：

Cytoplasm.
蛋白家族：

Glyceraldehyde-3-phosphate dehydrogenase family
組織特異性：

Testis specific.
數據庫鏈接：

HGNC: 24864

OMIM: 609169

KEGG: hsa:26330

STRING: 9606.ENSP00000222286

UniGene: Hs.248017

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