GALNT12 Antibody

中文名稱：

GALNT12兔多克隆抗體
貨號：

CSB-PA814224LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA814224LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA814224LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GALNT12 Polyclonal antibody
Uniprot No.：

Q8IXK2
基因名：

GALNT12
別名：

Colorectal cancer susceptibility to 1 antibody; CRCS1 antibody; FLJ21212 antibody; GalNAc T12 antibody; GalNAc-T12 antibody; GalNAcT12 antibody; GALNT 12 antibody; Galnt12 antibody; GLT12_HUMAN antibody; Polypeptide GalNAc transferase 12 antibody; Polypeptide N acetylgalactosaminyltransferase 12 antibody; Polypeptide N-acetylgalactosaminyltransferase 12 antibody; pp GaNTase 12 antibody; pp-GaNTase 12 antibody; Protein UDP acetylgalactosaminyltransferase 12 antibody; Protein-UDP acetylgalactosaminyltransferase 12 antibody; UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12 antibody; UDP GalNAc polypeptide N acetylgalactosaminyltransferase antibody; UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GALNT12 Antibody (CSB-PA814224LA01HU)，的標記方式是Non-conjugated。對于GALNT12 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA814224LB01HU	GALNT12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA814224LC01HU	GALNT12 Antibody, FITC conjugated
Biotin	CSB-PA814224LD01HU	GALNT12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
基因功能參考文獻：
1. LOH analyses, glycosylation pattern tests and case-control studies, our results did not support the role of c.907G>A, p.(D303N) as a high-penetrance risk allele for polyposis CRC PMID: 29095867
2. Results rule out GALNT12 as a major high familial colorectal cancer susceptibility gene. Additional studies are required to provide further evidence about its role as a moderate/low susceptibility gene in familial aggregation of cancer. PMID: 24115450
3. we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes. PMID: 24038392
4. Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. PMID: 22461326
5. cloning and characterization PMID: 12135769
6. The expression of pp-GalNAc-T12 seems to be a negative marker especially of metastatic gastric and colorectal cancer PMID: 15557789
7. inactivating GALNT12 mutations were identified as acquired somatic mutations in a set of 30 microsatellite stable colon tumors. PMID: 19617566
顯示更多

收起更多
相關疾?。?/div>
Colorectal cancer 1 (CRCS1)
亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 2 family, GalNAc-T subfamily
組織特異性：

Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral c
數據庫鏈接：

HGNC: 19877

OMIM: 608812

KEGG: hsa:79695

STRING: 9606.ENSP00000364150

UniGene: Hs.47099

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human