FUNDC1 Antibody

說明書

中文名稱：

FUNDC1兔多克隆抗體
貨號：

CSB-PA006338
規格：

￥1090
圖片：
Western Blot analysis of AD293 cells using FUNDC1 Polyclonal Antibody

Western Blot analysis of AD293 cells using FUNDC1 Polyclonal Antibody
其他：

產品詳情

Uniprot No.：

Q8IVP5
基因名：

FUNDC1
別名：

FUNDC1; FUN14 domain-containing protein 1
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human FUNDC1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
基因功能參考文獻：
1. Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy. PMID: 28719148
2. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. PMID: 27653272
3. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. PMID: 27145933
4. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy. PMID: 27050458
5. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy. PMID: 25126723
6. FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. PMID: 24671035
7. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1. PMID: 22267086
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亞細胞定位：

Mitochondrion outer membrane; Multi-pass membrane protein.
蛋白家族：

FUN14 family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 28746

OMIM: 300871

KEGG: hsa:139341

STRING: 9606.ENSP00000367284

UniGene: Hs.7549

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