FSHB Antibody, FITC conjugated

說明書

中文名稱：

FSHB兔多克隆抗體, FITC偶聯
貨號：

CSB-PA12335C0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FSHB Polyclonal antibody
Uniprot No.：

P01225
基因名：

FSHB
別名：

FSHBFollitropin subunit beta antibody; Follicle-stimulating hormone beta subunit antibody; FSH-B antibody; FSH-beta antibody; Follitropin beta chain antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Follitropin subunit beta protein (19-129AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
基因功能參考文獻：
1. High follicle stimulating hormone expression is associated with Turner syndrome. PMID: 29415703
2. We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level. PMID: 28901453
3. the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated. PMID: 27561202
4. Genetic variation affecting FSH production (FSHB c.-211G>T) was associated with age at pubertal onset, as assessed by testicular enlargement. The effect appeared further modified by coexistence of genetic variation affecting FSH sensitivity (FSHR c.-29G>A). PMID: 28323923
5. A novel homozygous mutation in the FSHbeta gene (c.343C > T) identified in a male patient with isolated FSH deficiency and infertility. PMID: 28392474
6. Association of the FSHB 211G > T polymorphism with male infertility in Han-Chinese PMID: 28764642
7. Genetic variations of FSH signaling appear to determine the individual set point of the hypothalamic-pituitary-gonadal axis already early in life. PMID: 27270476
8. Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency PMID: 28385888
9. Variants in FSHB gene are associated with polycystic ovary syndrome and LH levels in Han Chinese women. PMID: 26938199
10. Data indicate that compared with normal eggs, oocytes with a brown zona pellucida (ZP) were found to have a higher ZP thickness (ZPT), lower embryo quality and lower pregnancy rate, which might be due to a high gonadotropin (Gn) dosage injection and high serum follicle stimulating hormone (FSH) levels. PMID: 27442586
11. genetic association studies in peripubertal girls in Denmark: Data suggest that an SNP in FSHR (follicle stimulating hormone receptor, c.2039A>G) is associated with blood levels of FSH, LH, and estradiol; minor alleles in FSHB (follicle stimulating hormone beta subunit, c.-211G>T) and FSHR (c.-29G>A) are associated with delayed pubertal onset. PMID: 26905078
12. The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome PMID: 25052309
13. 3 known FSH-action modulating SNPs (FSHB -211G/T; FSHR -29G/A, c.2039 A/G)explained together 2.3%, 1.4%, 1.0 and 1.1% of the measured variance in serum FSH, Inhibin B, testosterone and total testes volume, respectively. PMID: 24718625
14. The combined effect of FSHB GG+FSHR AA may potentiate the FSH pathway, which increases serum levels of FSH and reduces antimullerian hormone in health girls. PMID: 23850305
15. Serum FSH levels are affected by the combination of genetic polymorphisms in FSHR and FSHB PMID: 23504007
16. Data suggest that low serum FSH levels in men with an SNP in promoter region of FSHB (-211G/T) result from reduced binding of LHX3 (LIM homeobox 3) to FSHB promoter/response element and down-regulation of FSHB transcription in gonadotrophs. PMID: 23766128
17. activin-regulated transcription mediated by forkhead box L2 [review] PMID: 23426431
18. Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH) is a suitable surrogate for determination of sperm concentration in a semen sample. PMID: 23423746
19. Ser680 genotype for FSHR is a factor of relative resistance to FSH stimulation resulting in slightly higher FSH serum levels, thus leading to a prolonged duration of the menstrual cycle. PMID: 23380184
20. Phenotypic consequences of FSHB -211G-->T on the hypothalamic-pituitary-ovarian axis in women. PMID: 23118424
21. Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth. PMID: 23160221
22. Negative fetal FSH/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R expression in the tuberal hypothalamus. PMID: 23015653
23. In the proposed model of the combined effects, FSHB -211G>T acts strongly on male reproductive parameters, whereas the FSHR 2039A>G effects were approximately 2-3 times smaller. PMID: 22791757
24. [review] A middle-aged male with feminizing adrenocortical (ACC) tumor shows delayed response of luteinizing hormone and poor response of FSH to gonadotropin-releasing hormone administration. PMID: 21720063
25. FSHB -211 TT genotype might represent a novel treatable form of male infertility characterized by severe spermatogenic impairment and low or inappropriately normal FSH plasma levels. PMID: 22000911
26. We showed for the first time that genetically determined low FSH may have wider downstream effects on the male reproductive system, including impaired testes development, altered testicular hormone levels and affected male reproductive potential. PMID: 21733993
27. Polymorphisms in the 5'-flanking regions of FSHbeta and luteinizing hormone (LH)beta genes are probably related to the puberty onset time of Chinese Han girls. PMID: 20869425
28. FSH dysfunction due to a less acidic isoform pattern through hypoglycosylation is not a key mechanism of primary ovarian insufficiency in classic galactosemia PMID: 20814826
29. Smad2 expression in ovarian cells requires a functional interplay between activin A (INHBA) and FSH/PKA signaling. PMID: 12665510
30. The level of serum FSH may be related to bone loss and the occurrence of osteoporosis in Chinese women. PMID: 19734592
31. Findings demonstrate that FSH has dose-dependent anabolic effects on bone via an ovary-dependent mechanism. PMID: 21149714
32. the genomic and genetic context of the FSHB and the LHB/CGB genes largely affects the profile of the hormone production PMID: 20488225
33. FoxL2 plays a key role in activin induction of the FSHbeta gene, by binding to sites conserved across multiple species. PMID: 20233786
34. This genetic marker may have clinical significance in molecular diagnostics of male reproductive success. PMID: 19897680
35. Review. The Asn7 and Asn24 glycosylation variants of human pituitary FSHB exhibit differential and divergent effects at the target cell level and that less sialylated, short-lived variants may exert significant effects in in vivo conditions. PMID: 11900895
36. FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia PMID: 12161499
37. Follicle-stimulating hormone interacts with exoloop 3 of the receptor. PMID: 12374801
38. A Cys82Arg mutation in this protein causes FSH deficiency in FSH levels in vitro. PMID: 12568849
39. No mutation in this gene can still cause FSH deficiency in a person with normal virilization. PMID: 12568861
40. x-ray crystallographic analysis shows that the FSH beta subunit is close to the N-terminal region and the alpha subunit is projected toward exoloop 3 in the endodomain PMID: 12963710
41. pituitary exit of LH and FSH occur via different secretion pathways, and are released spatially from the pituitary via different circulatory routes. PMID: 14585810
42. LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell. PMID: 15271874
43. Sequence analysis shows that the human FSH beta gene is highly conserved and amino acid changing mutations are apparently extremely rare; only three silent polymorphisms, two of which are novel, are revealed. PMID: 16100240
44. The strategy to produce a soluble FSH-FSHR complex that involves the co-secretion of a truncated FSHR ectodomain (FSHR(HB)) and a covalently linked FSHalphabeta heterodimer, is described. PMID: 17045735
45. A major regulatory mechanism for FSH glycosylation involves control of beta-subunit N-glycosylation, possibly by inhibition of oligosaccharyl transferase. Two primate species exhibited the same all-or-none pattern of pituitary FSHbeta glycosylation. PMID: 17079072
46. There is a preliminary observation suggesting that the second most frequent FSHB haplotype may be associated with rapid conception success in females. PMID: 17227474
47. Follitropin beta and, more precisely, follitropin alfa suppress the spectral components and power of the myoelectrical signals, which provides uterine quiescence. PMID: 18068163
48. Case Report: Isolated FSH deficiency without mutation of the FSHbeta gene and successful treatment with human menopausal gonadotropin. PMID: 18402948
49. A polymorphism within the FSHB gene is associated with serum FSH levels in men. PMID: 18567894
50. Ghrelin suppresses the secretion of FSH in humans. PMID: 19054012
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相關疾病：

Hypogonadotropic hypogonadism 24 without anosmia (HH24)
亞細胞定位：

Secreted.
蛋白家族：

Glycoprotein hormones subunit beta family
數據庫鏈接：

HGNC: 3964

OMIM: 136530

KEGG: hsa:2488

STRING: 9606.ENSP00000254122

UniGene: Hs.36975

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