FRS3 Antibody
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中文名稱：FRS3兔多克隆抗體
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貨號(hào)：CSB-PA002585
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of COS7 cells using FRS3 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：FRS3
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別名：FRS3Fibroblast growth factor receptor substrate 3 antibody; FGFR substrate 3 antibody; FGFR-signaling adaptor SNT2 antibody; Suc1-associated neurotrophic factor target 2 antibody; SNT-2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Monkey
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免疫原：Synthesized peptide derived from the Internal region of Human FRS3.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
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基因功能參考文獻(xiàn)：
- Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor. PMID: 20228838
- an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings PMID: 23279575
- FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors PMID: 11877385
- FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts PMID: 15094036
- SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2 PMID: 15485655
- Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2. PMID: 16702953
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亞細(xì)胞定位：Membrane; Lipid-anchor.
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數(shù)據(jù)庫(kù)鏈接：
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