FREM2 Antibody

中文名稱：

FREM2兔多克隆抗體
貨號：

CSB-PA722558LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA722558LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with CSB-PA722558LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FREM2 Polyclonal antibody
Uniprot No.：

Q5SZK8
基因名：

FREM2
別名：

DKFZp781I048 antibody; ECM3 homolog antibody; FRAS1-related extracellular matrix protein 2 antibody; FREM 2 antibody; Frem2 antibody; FREM2_HUMAN antibody; KIAA1074 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human FRAS1-related extracellular matrix protein 2 protein (1986-2127AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FREM2 Antibody (CSB-PA722558LA01HU)，的標記方式是Non-conjugated。對于FREM2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA722558LB01HU	FREM2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA722558LC01HU	FREM2 Antibody, FITC conjugated
Biotin	CSB-PA722558LD01HU	FREM2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs.
基因功能參考文獻：
1. FREM2 is thus proposed as a novel GB biomarker and a putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1 are expressed on the surface of the GB cells, while SPRY1 alone was found overexpressed in the cytosol of non-malignant astrocytes. PMID: 29734672
2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
3. Amplification of the FREM2 gene is associated with mesenchymal differentiation in gliosarcoma. PMID: 22538188
4. Heterozygous missense mutations in FREM2 cause non-syndromic congenital abnormalities of the kidney and urinary tract in humans. PMID: 21900877
5. report on 2 fetuses affected by Fraser syndrome (FS); a homozygous IVS14 + 1G -- A mutation in FREM2 was indentified; present report provides additional evidence that FS may be caused by complete or near-complete lack or loss of function of FREM2 protein PMID: 18203166
6. 1 new mutation in FREM2 was identified in families with Fraser syndrome. PMID: 18671281
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相關疾病：

Fraser syndrome 2 (FRASRS2)
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

FRAS1 family
數據庫鏈接：

HGNC: 25396

OMIM: 608945

KEGG: hsa:341640

STRING: 9606.ENSP00000280481

UniGene: Hs.253994

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