FPR3 Antibody

評價 (1) 說明書

中文名稱：

FPR3兔多克隆抗體
貨號：

CSB-PA008856LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008856LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008856LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA008856LA01HU at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) FPR3 Polyclonal antibody
Uniprot No.：

P25089
基因名：

FPR3
別名：

FPR3; FPRH1; FPRL2; N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human N-formyl peptide receptor 3 protein (307-353AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，F(xiàn)PR3 Antibody (CSB-PA008856LA01HU)，的標(biāo)記方式是Non-conjugated。對于FPR3 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA008856LB01HU	FPR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008856LC01HU	FPR3 Antibody, FITC conjugated
Biotin	CSB-PA008856LD01HU	FPR3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

平均分:

5.0分 - 1 個評價

實驗應(yīng)用：IHC

樣品信息：乳腺癌人

稀釋比：1：150

產(chǎn)品評價：我使用CSB-PA008856LA01HU抗體，進行乳腺癌患者免疫組化檢測，按照1：150稀釋度，能夠達到較好的結(jié)果。推薦使用。

By 唐老師

靶點詳情

功能：

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin.
基因功能參考文獻：
1. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis. PMID: 23746112
2. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution. PMID: 21717223
3. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils PMID: 21709160
4. Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. PMID: 20972812
5. Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 & its endogenous ligand may be involved in regulating DC trafficking during Ag uptake & processing s well as the T-cell-stimulating phase of the immune responses. PMID: 12223529
6. Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. PMID: 16002663
7. However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases, and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. PMID: 17577578
8. FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions PMID: 19342677
9. Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. PMID: 19843937
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Detected in various tissues with highest expression in lung.
數(shù)據(jù)庫鏈接：

HGNC: 3828

OMIM: 136539

KEGG: hsa:2359

STRING: 9606.ENSP00000341821

UniGene: Hs.445466

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