FMN1 Antibody

中文名稱：

FMN1兔多克隆抗體
貨號：

CSB-PA715012LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: K562 whole cell lysate, A549 whole cell lysate
All lanes: FMN1 antibody at 3.9µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 158, 72, 54, 133 kDa
Observed band size: 158 kDa

IHC image of CSB-PA715012LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA715012LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FMN1 Polyclonal antibody
Uniprot No.：

Q68DA7
基因名：

FMN1
別名：

FMN1 antibody; FMN antibody; LDFormin-1 antibody; Limb deformity protein homolog antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Formin-1 protein (354-487AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FMN1 Antibody (CSB-PA715012LA01HU)，的標記方式是Non-conjugated。對于FMN1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA715012LB01HU	FMN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA715012LC01HU	FMN1 Antibody, FITC conjugated
Biotin	CSB-PA715012LD01HU	FMN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in the formation of adherens junction and the polymerization of linear actin cables.
基因功能參考文獻：
1. Formin-1 (FMN1) was shown to reside in the nucleus and studies indicate that some formins can shuttle in and out of the nucleus. PMID: 27913680
2. actin arcs populating the medial, lamella-like region of the immunological synapse (IS) arise from linear actin filaments generated by one or more formins present at the IS distal edge. PMID: 27799367
3. Filopodia initiation: focus on the Arp2/3 complex and formins. PMID: 21975549
4. Chromosomal imbalances in the GREM1 FMN1 region in individuals with limb defects are reported here. PMID: 20610440
5. The obtained data indicate the possibility of participation of polymorphism in gene FMN1 in formation of predisposition to prostate cancer. PMID: 20540360
6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20540360
8. Observational study of gene-disease association. (HuGE Navigator) PMID: 20200978
9. both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2 PMID: 19605360
10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19096130
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亞細胞定位：

Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Formin homology family, Cappuccino subfamily
數據庫鏈接：

HGNC: 3768

OMIM: 136535

KEGG: hsa:342184

STRING: 9606.ENSP00000333950

UniGene: Hs.657649

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