FGFBP1 Antibody

說明書

中文名稱：

FGFBP1兔多克隆抗體
貨號：

CSB-PA623920ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: Fibroblast growth factor-binding protein 1 antibody at 5μg/ml + Mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 26 kDa
Observed band size: 26 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA623920ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA623920ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FGFBP1 Polyclonal antibody
Uniprot No.：

Q14512
基因名：

FGFBP1
別名：

17 kDa HBGF-binding protein antibody; 17 kDa heparin binding growth factor binding protein antibody; 17 kDa heparin-binding growth factor-binding protein antibody; FGF binding protein 1 antibody; FGF BP antibody; FGF BP1 antibody; FGF-binding protein 1 antibody; FGF-BP antibody; FGF-BP1 antibody; FGFBP antibody; FGFBP-1 antibody; Fgfbp1 antibody; FGFP1_HUMAN antibody; Fibroblast growth factor binding protein 1 precursor antibody; Fibroblast growth factor-binding protein 1 antibody; HBp17 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Fibroblast growth factor-binding protein 1protein (24-234AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
基因功能參考文獻：
1. These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells. PMID: 27121396
2. Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension. PMID: 29158353
3. Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. PMID: 25704764
4. overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. PMID: 23592278
5. FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations. PMID: 21436287
6. Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk. PMID: 20450993
7. Upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair. PMID: 15806171
8. the FGF interaction domain is contained in the C terminus of FGF-BP1 PMID: 16257968
9. FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review] PMID: 16324873
10. The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease. PMID: 16352855
11. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. PMID: 19411256
12. KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription. PMID: 19668233
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亞細胞定位：

Secreted, extracellular space. Cell membrane; Peripheral membrane protein.
蛋白家族：

Fibroblast growth factor-binding protein family
組織特異性：

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carc
數據庫鏈接：

HGNC: 19695

OMIM: 607737

KEGG: hsa:9982

STRING: 9606.ENSP00000259988

UniGene: Hs.1690

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