FBXL2 Antibody

中文名稱：

FBXL2兔多克隆抗體
貨號：

CSB-PA892134LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA892134LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FBXL2 Polyclonal antibody
Uniprot No.：

Q9UKC9
基因名：

FBXL2
別名：

DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FBXL2 Antibody (CSB-PA892134LA01HU)，的標記方式是Non-conjugated。對于FBXL2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA892134LB01HU	FBXL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892134LC01HU	FBXL2 Antibody, FITC conjugated
Biotin	CSB-PA892134LD01HU	FBXL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.
基因功能參考文獻：
1. PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
2. these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. PMID: 26790640
3. FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. PMID: 26037928
4. FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
5. These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. PMID: 22455980
6. FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor PMID: 22020328
7. FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PMID: 22323446
8. FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. PMID: 22399757
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亞細胞定位：

Membrane; Lipid-anchor.
組織特異性：

Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
數據庫鏈接：

HGNC: 13598

OMIM: 605652

KEGG: hsa:25827

STRING: 9606.ENSP00000417601

UniGene: Hs.475872

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