FASTK Antibody
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中文名稱：FASTK兔多克隆抗體
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貨號(hào)：CSB-PA997710
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規(guī)格：￥1100
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圖片：
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The image is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA997710(FASTK Antibody) at dilution 1/30. (Original magnification: ×200) -
The image is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA997710(FASTK Antibody) at dilution 1/30. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：FASTK
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別名：Fas activated serine threonine kinase antibody; Fas-activated serine/threonine kinase antibody; FAST antibody; FAST kinase antibody; FASTK antibody; FASTK_HUMAN antibody; FLJ13079 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Fusion protein of Human FASTK
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.; Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
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基因功能參考文獻(xiàn)：
- FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis. PMID: 25704814
- MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK. PMID: 24013584
- FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls. PMID: 20363972
- FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression. PMID: 15572676
- FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing PMID: 17135269
- Nuclear FAST can regulate the splicing of FGFR2 transcripts. PMID: 17592127
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亞細(xì)胞定位：[Isoform 4]: Mitochondrion matrix.
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蛋白家族：FAST protein kinase family
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組織特異性：Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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數(shù)據(jù)庫(kù)鏈接：
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