FAAP20 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FAAP20 Polyclonal antibody
Uniprot No.：

Q6NZ36
基因名：

FAAP20
別名：

C1orf86 antibody; CA086_HUMAN antibody; Chromosome 1 open reading frame 86 antibody; FAAP20 antibody; Fanconi anemia associated protein of 20 kDa antibody; FP7162 antibody; RP11-181G12.3 antibody; Uncharacterized protein C1orf86 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Fanconi anemia core complex-associated protein 20 protein (14-179AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
基因功能參考文獻：
1. Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). PMID: 26318859
2. FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway. PMID: 22343915
3. FAAP20-ubiquitin interaction expands beyond the compact UBZ domain and requires the folding and interaction of the otherwise disordered C-terminal tail of FAAP20 for high-affinity binding. PMID: 25414354
4. Data indicate that RNF8 and FAAP20 (C1orf86) are needed for efficient Fanconi anemia group D2 protein FANCD2 monoubiquitination. PMID: 22705371
5. FAAP20 is an important player involved in the Fanconi anemia pathway PMID: 22396592
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亞細胞定位：

Nucleus. Chromosome.
數據庫鏈接：

HGNC: 26428

OMIM: 615183

KEGG: hsa:199990

STRING: 9606.ENSP00000367808

UniGene: Hs.107101

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