ETS2 Antibody, Biotin conjugated
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中文名稱：ETS2兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA007853LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ETS2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：C ets 2 protein antibody; ETS2 antibody; ETS2_HUMAN antibody; ETS2IT1 antibody; Oncogene ETS 2 antibody; Oncogene ETS2 antibody; Protein C-ets-2 antibody; v ets avian erythroblastosis virus E2 oncogene homolog 2 antibody; V ets avian erythroblastosis virus E26 oncogene homolog 2 antibody; V ets erythroblastosis virus E26 oncogene homolog 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Protein C-ets-2 protein (9-185AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
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基因功能參考文獻(xiàn)：
- ETS2 is of potential value as a molecular target for RCC treatment. PMID: 29772431
- ETS2 functions as an oncogene and plays a key role in the progression of hypopharyngeal cancer. PMID: 29111780
- ETS2 (high) is a poor prognostic factor in acute myeloid leukemia and may guide treatment decisions towards allogeneic hematopoietic stem cell transplantation. PMID: 28724426
- Findings strongly suggest a critical role of Ets2 in human esophageal squamous cell carcinoma pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway. PMID: 27556183
- Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. PMID: 26871468
- These findings suggest that ETS2 rs461155A>G, could be used as a biomarker predicting the clinical outcomes of non-small cell lung cancer patients treated with first-line paclitaxel-cisplatin chemotherapy. PMID: 26893365
- These results suggest an unappreciated role for ETS2 in fibroblasts in establishing an immune-suppressive microenvironment in response to oncogenic Kras(G12D) signaling during the initial stages of tumor development. PMID: 27659014
- ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 PMID: 27048589
- Neuronal C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes. PMID: 27195074
- ETS2, HNF4A and JUNB are synergistic master regulators of epithelial-to-mesenchymal transition in cancer. PMID: 26926107
- ATO treatment upregulated Ets-2 and miR-126 expression in HUVECs. PMID: 26274316
- RNA-seq evidence of biallelic expression of ETS2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of ETS2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
- ETS-1/ETS-2 and C/EBPalpha could interact with corresponding binding sites. PMID: 25726912
- These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells. PMID: 25680408
- The crystal structure of a DNA complex of the Ets-2 Ets domain. PMID: 25670864
- identified Ets2 as a key novel regulator in both the positive and negative control of miR-155 in the inflammatory response. PMID: 24362029
- The data reveals a key function for Ets2 in tumor fibroblasts in signaling to endothelial cells to promote tumor angiogenesis. PMID: 23977064
- Our findings point to a tumor suppressor role for ETS2 in human NSCLC pathogenesis through inhibition of the MET proto-oncogene. PMID: 23659968
- hepatitis B virus core protein enhanced the promoter activity of human telomerase reverse transcriptase, which was dependent on the binding of c-Ets2 to the promoter region PMID: 23542016
- the G allele of SNP rs391957 in the promoter of GRP78 was strongly associated with increased hepatocellular carcinoma risk and cis-regulated GRP78 expression by providing an Ets-2 binding site. PMID: 23416888
- The Ets2 transcription factor regulates G-CSF expression in human cancer. PMID: 23530240
- Altered expression of SIM2 and ETS2 could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome. PMID: 23343470
- Data suggest that the regulation of MDR1 expression by ETS2 may provide potential ways to overcome MDR in cancer treatment. PMID: 22819965
- Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. PMID: 22826236
- In embryonic stem cells [which express ETS2 (proto-oncogene c-ETS-2) but not CGA (alpha subunit chorionic gonadotropin)], ETS2 does not occupy binding site on CGA promoter but is found as soluble complex with POU5F1 (Oct3 transcription factor). PMID: 22446105
- c-Jun in cooperation with Ets2 increases the expression of Syk and contributes to Syk-mediated heightened calcium responses in systemic lupus erythematosus T cells. PMID: 22354960
- demonstrated that miR-196b was transcriptionally regulated by ETS2 and there was an inverse expression profile between miR-196b and ETS2 in clinical samples PMID: 22298639
- a stage-specific Ets-1-independent regulatory role for Ets-2 in early thymocyte development and survival PMID: 22128184
- rs461155 and rs2073601, in ETS2 and SIM2 genes respectively, showed significant redundant interaction in probands with Down syndrome PMID: 22048266
- These data indicate the importance of phosphorylated ets-2 in the pathogenesis of pulmonary fibrosis through the expression of Type I collagen and (myo)fibroblast activation. PMID: 21562315
- evidence for the plaque-destabilizing role of Ets2 in atherosclerosis development by induction of an intraplaque proinflammatory phenotype in endothelial cells. PMID: 21700929
- data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences PMID: 21763315
- Allelic discrimination of deleterious SNPs in ETS2 may play a regulatory role in the differential development of malignancy in Down syndrome subjects. PMID: 21526717
- the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
- Ets2 is a central driver of a transcriptional program in tumor-associated macrophages that acts to promote lung metastasis of breast tumors. PMID: 20145133
- Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2. PMID: 19939245
- Linkage of elevated expression to hepatocarcinogenesis PMID: 12174931
- Two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin beta5 (hCGbeta5) gene constitute a major enhancer for hCGbeta gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells. PMID: 12511603
- Overexpression of ETS2 in human esophageal squamous cell carcinoma in both mRNA and protein levels. PMID: 12532432
- ets-2 has a role as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors PMID: 12637547
- ETS2 is a target of protein kinase C and upregulates GM-CSF PMID: 12646185
- Ets-2 and its targets play essential roles in endothelial cell function PMID: 14507917
- Ras/mitogen-activated kinase signaling activates ETS2 by CBP/p300 recruitment. PMID: 15572696
- Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer PMID: 15788656
- Phosphorylated ERK1/2 was further associated with the presence of VEGFR2 (cohorts II and III) and the degree of phosphorylated Ets-2, indicating in vivo, a signalling cascade from VEGFR2 via ERK1/2 to Ets-2 phosphorylation PMID: 15806151
- analysis of Ets2 in cell-seeded three-dimensional bone constructs PMID: 15900611
- Data show that transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site. PMID: 16953216
- Results suggest that there is a strong interplay of Ets2 with bone-specific proteins in cell-seeded three-dimensional bone constructs. PMID: 17703088
- data of study population indicate a higher ETS2 RNA concentration compared with uPA in the case of bladder cancer, resulting in an increased ETS2:uPA RNA ratio in urine PMID: 17921261
- Data show that there are combinatorial effects of Ets2, PKA, and CBP/p300 and triggered via growth factors released from maternal endometrium. PMID: 17975022
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亞細(xì)胞定位：Nucleus.
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蛋白家族：ETS family
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