ETFB Antibody
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中文名稱：ETFB兔多克隆抗體
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貨號：CSB-PA007845GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ETFB
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別名：Beta ETF antibody; Beta-ETF antibody; Electron transfer flavoprotein beta polypeptide antibody; Electron transfer flavoprotein beta subunit antibody; Electron transfer flavoprotein subunit beta antibody; Electron transferring flavoprotein beta polypeptide antibody; etfB antibody; ETFB_HUMAN antibody; FP585 antibody; MADD antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human ETFB
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
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基因功能參考文獻(xiàn)：
- We identified and replicated a novel gene, ETFB, strongly associated with chronic anthracycline-induced cardiotoxicity independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction PMID: 28913729
- These results suggested that increasing levels of ATP5B and ETFB were associated with worsening renal injury. PMID: 27840937
- the findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN. PMID: 27035869
- Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behcet's Disease PMID: 25915519
- Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. PMID: 25416781
- ETFB knockdown can affect TGF-beta-induced tissue remodeling and/or fibrotic processes in vitro. PMID: 23068445
- Point mutations in electron-transfer-flavoprotein beta is associated with destabilized conformations and defective protein:protein interactions leading to mitochondrial dysfunction. PMID: 22588007
- ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. PMID: 21903359
- non-productive conformation stabilization underpins rapid electron transfer to electron-transferring flavoprotein PMID: 15975918
- Tissue samples from 16 unrelated patients with ETF deficiency were analysed, two of them harboured mutations in the ETFB gene. PMID: 16510302
- conformational and stability properties of the disease-causing variant ETFbeta-D128N, and our findings on the effect of flavinylation in modulating protein conformational stability and activity. PMID: 19088074
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相關(guān)疾病：Glutaric aciduria 2B (GA2B)
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亞細(xì)胞定位：Mitochondrion matrix.
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蛋白家族：ETF beta-subunit/FixA family
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組織特異性：Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
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數(shù)據(jù)庫鏈接：
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