EPG5 Antibody
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中文名稱：EPG5兔多克隆抗體
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貨號：CSB-PA080167
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規格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded Mouse Liver Tissue using EPG5 Polyclonal Antibody. -
Western blot analysis of Rat Liver Tissue using EPG5 Polyclonal Antibody.
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其他：
產品詳情
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Uniprot No.：
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基因名：EPG5
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別名：Ectopic P granules autophagy protein 5 homolog (C. elegans) antibody; Ectopic P granules protein 5 homolog antibody; Epg5 antibody; EPG5_HUMAN antibody; HEEW1 antibody; hEPG5 antibody; KIAA1632 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Recombinant Protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-2000 IHC 1:200-500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.
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基因功能參考文獻：
- Our findings expand the phenotypical spectrum of EPG5-related Vici syndrome and suggest that this severe condition may already present in utero PMID: 28748650
- Our report further reinforces that EPG5-related Vici syndrome is both a neurodevelopmental disorder, which can be diagnosed as early as the second trimester of pregnancy, as well as a neurodegenerative disorder. PMID: 28168853
- The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. PMID: 27588602
- Seven SNPs were significantly associated with the risk of Alzheimer disease, and eight SNPs were associated with the age at onset of AD. PMID: 27586004
- We report two sisters with a nonsense mutation within exon 14 of the EPG5 gene and a phenotype consistent with Vici syndrome PMID: 26854214
- This article confirms in silico predictions of aberrant splicing in the EPG5 gene due to the mutation NM_020964.2; c.1007A>G p.Gln336Arg PMID: 27343256
- A mutation affecting the penultimate exon of EPG5 and presenting with typical clinical manifestations of Vici syndrome. PMID: 25331754
- Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. PMID: 23222957
- We characterized the KIAA1632 gene by computational methods: detailed investigation of the genomic structure, protein prediction, identification of orthologs in other species and phylogenetic analysis. PMID: 17549423
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相關疾病：Vici syndrome (VICIS)
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亞細胞定位：Cytoplasm, perinuclear region. Lysosome.
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蛋白家族：EPG5 family
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數據庫鏈接：
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Species Reactivity: Human, Mouse, Rat
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