EPB41L2 Antibody

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) EPB41L2 Polyclonal antibody
Uniprot No.：

O43491
基因名：

EPB41L2
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Internal of Human EPB41L2.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
基因功能參考文獻：
1. Ca(2+)/CaM binding to GHP, and more specifically to pepG, has profound effects on other functional domains of 4.1G PMID: 23354586
2. 4.1G protein depresses PTH-related protein receptor-mediated Gs signaling pathway by suppression of adenylyl cyclase-mediated cAMP production. PMID: 23201780
3. A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling. PMID: 22003208
4. PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex PMID: 15138281
5. An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. PMID: 18023480
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 3379

OMIM: 603237

KEGG: hsa:2037

STRING: 9606.ENSP00000338481

UniGene: Hs.486470

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