EMX2 Antibody, Biotin conjugated

說明書

中文名稱：

EMX2兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA007657LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) EMX2 Polyclonal antibody
Uniprot No.：

Q04743
基因名：

EMX2
別名：

Empty spiracles homeobox 2 antibody; Empty spiracles homolog 2 (Drosophila) antibody; Empty spiracles homolog 2 antibody; Empty spiracles like protein 2 antibody; Empty spiracles-like protein 2 antibody; EMX 2 antibody; EMX2 antibody; EMX2_HUMAN antibody; Homeobox protein EMX 2 antibody; Homeobox protein EMX2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Homeobox protein EMX2 protein (75-141AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
基因功能參考文獻(xiàn)：
1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. PMID: 28830374
2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences. PMID: 27191499
3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells. PMID: 27712600
4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration. PMID: 26132438
5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion. PMID: 25577462
6. Deletions of EMX2 have been associated with a wide range of DSD. PMID: 24975717
7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. PMID: 25023662
8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer PMID: 23370654
9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo. PMID: 23029345
10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay. PMID: 21917011
11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma. PMID: 21726823
12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes PMID: 20697358
14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients. PMID: 12185771
15. In these studies we identify and characterize the regulation of EMX2 by HOXA10. PMID: 12482956
16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression. PMID: 15126568
17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas. PMID: 15294144
18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis. PMID: 17563403
19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations PMID: 18409201
20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents. PMID: 18973570
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相關(guān)疾病：

Schizencephaly (SCHZC)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

EMX homeobox family
組織特異性：

Cerebral cortex.
數(shù)據(jù)庫鏈接：

HGNC: 3341

OMIM: 269160

KEGG: hsa:2018

STRING: 9606.ENSP00000358202

UniGene: Hs.202095

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