ELF2 Antibody

中文名稱：

ELF2兔多克隆抗體
貨號：

CSB-PA618015LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of SH-SY5Y cells with CSB-PA618015LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ELF2 Polyclonal antibody
Uniprot No.：

Q15723
基因名：

ELF2
別名：

ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor), ELF2, NERF
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ETS-related transcription factor Elf-2 protein (1-353aa)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ELF2 Antibody (CSB-PA618015LA01HU)，的標記方式是Non-conjugated。對于ELF2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA618015LB01HU	ELF2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA618015LC01HU	ELF2 Antibody, FITC conjugated
Biotin	CSB-PA618015LD01HU	ELF2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:100-1:500

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; Isoform 2 may function in repression of RUNX1-mediated transactivation.
基因功能參考文獻：
1. Mutations in eIF2B genes cause vanishing white matter disease due to translation defects. PMID: 29632131
2. Our findings collectively support a potential role of triiodothyronine and its receptor in tumor growth inhibition through regulation of ELF2 PMID: 26968954
3. PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway. PMID: 28728844
4. angiopoietin-1 regulates expression of NERF2 and its own receptor in hypoxic cells. PMID: 11967990
5. NERF/ELF-2 physically interacts with AML1 and mediates opposing effects on AML1-mediated transcription of the B cell-specific blk gene PMID: 14970218
6. These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress. PMID: 17368566
7. ELF2 transactivates VCP promoter through binding to two motifs, with a predominant contribution of the upstream one. PMID: 18544453
8. Affinity of the CAL PDZ domain for the cystic fibrosis transmembrane conductance regulator (CFTR) C-terminus is much weaker than that of the NHERF1/NHERF2 domains, enabling wild-type CFTR to avoid premature entrapment in the lysosomal pathway. PMID: 18754678
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亞細胞定位：

Nucleus.
蛋白家族：

ETS family
組織特異性：

Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung,
數據庫鏈接：

HGNC: 3317

KEGG: hsa:1998

STRING: 9606.ENSP00000265495

UniGene: Hs.634040

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