EIF4ENIF1 Antibody
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中文名稱：EIF4ENIF1兔多克隆抗體
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貨號：CSB-PA873633LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: HEK293 whole cell lysate, A549 whole cell lysate, Mouse brain tissue
All lanes: EIF4ENIF1 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 109, 89 kDa
Observed band size: 130 kDa -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873633LA01HU at dilution of 1:100 -
Immunofluorescent analysis of MCF-7 cells using CSB-PA873633LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) EIF4ENIF1 Polyclonal antibody
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Uniprot No.：
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基因名：EIF4ENIF1
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別名：2610509L04Rik antibody; 4E T antibody; 4E-T antibody; 4ET antibody; 4ET_HUMAN antibody; A930019J01Rik antibody; AA410001 antibody; AU021239 antibody; Clast 4 antibody; Clast4 antibody; D11Ertd166e antibody; eIF4E transporter antibody; Eif4enif1 antibody; Eukaryotic translation initiation factor 4E nuclear import factor 1 antibody; Eukaryotic translation initiation factor 4E transporter antibody; FLJ21601 antibody; FLJ26551 antibody; OTTMUSP00000000698 antibody; OTTMUSP00000005193 antibody; OTTMUSP00000005194 antibody; OTTMUSP00000036075 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Eukaryotic translation initiation factor 4E transporter protein (340-630AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，EIF4ENIF1 Antibody (CSB-PA873633LA01HU)，的標記方式是Non-conjugated。對于EIF4ENIF1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.
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基因功能參考文獻：
- we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
- our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap PMID: 26027925
- neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. PMID: 25456498
- that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions PMID: 23991149
- This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. PMID: 24335285
- Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. PMID: 23902945
- The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. PMID: 22966201
- human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation PMID: 15840819
- A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. PMID: 16157702
- Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. PMID: 18343217
- Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality PMID: 19850929
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亞細胞定位：Cytoplasm, P-body. Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle.
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組織特異性：Widely expressed.
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數據庫鏈接：
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