EIF3I Antibody
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中文名稱：EIF3I兔多克隆抗體
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貨號(hào)：CSB-PA007538GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：EIF3I
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別名：eIF-3-beta antibody; eIF3 beta antibody; eIF3 p36 antibody; eIF3-beta antibody; eIF3-p36 antibody; eIF3i antibody; EIF3I_HUMAN antibody; EIF3S2 antibody; EIF3S2; formerly antibody; Eukaryotic translation initiation factor 3 subunit 2 antibody; Eukaryotic translation initiation factor 3 subunit 2 beta antibody; Eukaryotic translation initiation factor 3 subunit I antibody; eukaryotic translation initiation factor 3; subunit 2 (beta; 36kD antibody; eukaryotic translation initiation factor 3; subunit 2 beta; 36kDa antibody; eukaryotic translation initiation factor 3; subunit 2; formerly antibody; eukaryotic translation initiation factor 3; subunit I antibody; Predicted protein of HQ2242 antibody; PRO2242 antibody; TGF beta receptor interacting protein 1 antibody; TGF-beta receptor-interacting protein 1 antibody; TGFbeta receptor interacting protein 1 antibody; TGFbeta receptor-interacting protein 1 antibody; TRIP 1 antibody; TRIP-1 antibody; TRIP1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human EIF3I
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
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基因功能參考文獻(xiàn)：
- EIF3i may affect vesicular stomatitis virus (VSV) growth by regulating the host antiviral response in HeLa cells. PMID: 29173589
- High eIF3i expression is associated with melanoma. PMID: 28193911
- Clusterin is an independent predictive factor for prognosis of hepatocellular carcinoma and it facilitates metastasis through EIF3I/Akt/MMP13 signaling. PMID: 25609201
- eIF3i is a proto-oncogene that drives colon oncogenesis by translationally upregulating COX-2 and activating the beta-catenin signaling pathway PMID: 24056964
- findings report that short hairpin RNA mediated depletion of TRIP-1 gene transcripts in A549 cells promotes epithelial-mesenchymal transition (EMT); knockdown of TRIP-1 dramatically increased A549 responsiveness to TGF-beta1 induction of EMT PMID: 21378021
- eIF3i overexpression fosters the integration of growth signals by mTOR into the mRNA translation process, promoting protein synthesis and tumor growth. PMID: 16929481
- Subunit b of the eIF3 complex directly binds to HCV IRES domain III via its N-terminal-RRM. PMID: 19059401
- TGF-beta receptor interacting protein 1 (TRIP-1), which we show inhibits fibroblast collagen contraction, is higher in fetal than adult fibroblasts PMID: 19329541
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：EIF-3 subunit I family
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數(shù)據(jù)庫(kù)鏈接：
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