EIF3C Antibody

中文名稱：

EIF3C兔多克隆抗體
貨號：

CSB-PA857867LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate
All lanes: EIF3C antibody at 3.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 106, 105 kDa
Observed band size: 106 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA857867LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA857867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) EIF3C Polyclonal antibody
Uniprot No.：

Q99613
基因名：

EIF3C
別名：

Cell migration inducing protein 17 antibody; eIF 3c antibody; eIF3 p110 antibody; eIF3-p110 antibody; eIF3c antibody; EIF3C_HUMAN antibody; EIF3CL antibody; EIF3S8 antibody; EIF3S8 protein antibody; Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody; Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody; Eukaryotic translation initiation factor 3 subunit 8 antibody; Eukaryotic translation initiation factor 3 subunit C antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Eukaryotic translation initiation factor 3 subunit C protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，EIF3C Antibody (CSB-PA857867LA01HU)，的標(biāo)記方式是Non-conjugated。對于EIF3C Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA857867LB01HU	EIF3C Antibody, HRP conjugated	ELISA
FITC	CSB-PA857867LC01HU	EIF3C Antibody, FITC conjugated
Biotin	CSB-PA857867LD01HU	EIF3C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
基因功能參考文獻：
1. In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity. PMID: 28854163
2. High eIF3c expression is positively associated with KRAS. PMID: 28231410
3. These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. PMID: 25823503
4. eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
5. Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy. PMID: 23733421
6. These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation. PMID: 22016036
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

EIF-3 subunit C family
數(shù)據(jù)庫鏈接：

HGNC: 3279

OMIM: 603916

KEGG: hsa:8663

STRING: 9606.ENSP00000332604

UniGene: Hs.567374

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