EIF2S3 Antibody

說明書

中文名稱：

EIF2S3兔多克隆抗體
貨號：

CSB-PA007528ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: EIF2S3 antibody at 1.13µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007528ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) EIF2S3 Polyclonal antibody
Uniprot No.：

P41091
基因名：

EIF2S3
別名：

eIF-2-gamma X antibody; eIF-2gA antibody; eIF-2gX antibody; EIF2 antibody; EIF2G antibody; EIF2gamma antibody; EIF2S3 antibody; Eukaryotic translation initiation factor 2 gamma antibody; Eukaryotic translation initiation factor 2 gamma subunit antibody; Eukaryotic translation initiation factor 2 subunit 3 antibody; Eukaryotic translation initiation factor 2 subunit 3 gamma 52kDa antibody; Eukaryotic translation initiation factor 2 subunit gamma X antibody; IF2G_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Eukaryotic translation initiation factor 2 subunit 3 protein (173-472AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B. Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage.
基因功能參考文獻：
1. We aimed to provide more details on the endocrine phenotype in two previously reported male probands with MEHMO carrying a frame-shift mutation (I465fs) in the EIF2S3 gene PMID: 29303605
2. Data suggest that more severe EIF2S3 mutations cause the full MEHMO phenotype, while less deleterious mutations cause a milder form of the syndrome with only a subset of the symptoms. PMID: 28055140
3. Our data confirm that EIF2S3 mutation is implicated in a rare, but recognizable, form of syndromic intellectual disability. PMID: 27333055
4. The human X-chromosomal neurological disorder characterized by intellectual disability and microcephaly is caused by a missense mutation in eIF2gamma (encoded by EIF2S3), the core subunit of the heterotrimeric eIF2 complex. PMID: 23063529
相關疾病：

MEHMO syndrome (MEHMO)
蛋白家族：

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EIF2G subfamily
組織特異性：

Expressed in testis, brain, liver and muscle.
數據庫鏈接：

HGNC: 3267

OMIM: 300148

KEGG: hsa:1968

STRING: 9606.ENSP00000253039

UniGene: Hs.539684

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