EIF2B4 Antibody
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中文名稱：EIF2B4兔多克隆抗體
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貨號：CSB-PA933060
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HepG2 cells and LOVO cells, using EIF2B4 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) EIF2B4 Polyclonal antibody
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Uniprot No.：
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基因名：EIF2B4
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human EIF2B4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
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基因功能參考文獻：
- A novel missense mutation within EIF2B4 is associated with vanishing white matter disease. PMID: 25600065
- demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs PMID: 25779044
- The functional effects of selected vanishing white matter disease mutations in EIF2B2-5 by coexpressing mutated and wild-type subunits in human cells. PMID: 21560189
- analysis of developmental splicing deregulation in leukodystrophies related to EIF2B mutations PMID: 22737209
- A mutation .626G>A [p.Arg209Gln] in exon 7 and c.1399C>T [p.Arg467Trp] in exon 13 of the EIF2B4-Gens. PMID: 21503715
- Data demonstrate that cellular response resulting from eIF2alpha phosphorylation is attenuated in several cancer cell lines, and correlates with the expression of a specific isoform of a regulatory eIF2B subunit, eIF2Bdelta variant 1 (V1). PMID: 20709751
- These results validate the measurement of eIF2B GEF activity in patients' transformed-lymphocytes as an important tool for the diagnosis of eIF2B-related disorders. PMID: 20016818
- A unique EIF2B mutation spectrum in Chinese Vanishing white matter patients was shown. PMID: 19158808
- Mutation in EIF2B4 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. PMID: 12707859
- We report for the first time that in vitro fertilization and embryo transfer can lead to a successful procreation in patients with OLD related to EIF2B mutations. PMID: 18005052
- This study describe here a case suggestive of ovarioleukodistrophy carrying no eIF2B mutations. PMID: 18061208
- A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of EIF-2B, is reported. PMID: 18160716
- Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon) PMID: 18263758
- The authors suspected VWM and sequenced the genes EIF2B1-5, which revealed one heterozygous mutation in EIF2B4. PMID: 18330844
- We describe the first Chinese patient with typical clinical and radiological features genetically confirmed to have vanishing white matter disease for a mutation in EIF2B4. PMID: 18539998
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相關疾病：Leukodystrophy with vanishing white matter (VWM)
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蛋白家族：EIF-2B alpha/beta/delta subunits family
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數據庫鏈接：
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