EGR2 Antibody
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中文名稱：EGR2兔多克隆抗體
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貨號：CSB-PA007485GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：AT591 antibody; CMT1D antibody; CMT4E antibody; DKFZp686J1957 antibody; E3 SUMO-protein ligase EGR2 antibody; Early growth response 2 antibody; Early growth response protein 2 antibody; EGR-2 antibody; egr2 antibody; EGR2_HUMAN antibody; FLJ14547 antibody; KROX 20 Drosophila homolog antibody; Krox 20 homolog Drosophila antibody; KROX-20; Drosophila; homolog (early growth response-2) antibody; KROX20 antibody; Krox20 protein antibody; Zinc finger protein Krox-20 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human EGR2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB.; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
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基因功能參考文獻：
- Low EGR2 expression is associated with hepatocellular carcinoma. PMID: 28542387
- The study suggests that acetylation of EGR2 is regulated independently of nucleosome remodeling and deacetylase. PMID: 28576496
- Egr2-driven cell surface proteins LAG-3 and 4-1BB can identify dysfunctional tumor antigen-specific CD8(+) TIL. PMID: 28115575
- Egr2 and Egr3 have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 confer suppressive activity to CD4(+) T cells and regulate the production of inhibitory cytokines such as IL-10 and TGF-beta1. PMID: 27856665
- Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. PMID: 27890615
- In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS. PMID: 27667480
- EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity. PMID: 26204789
- MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression. PMID: 26238942
- These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome PMID: 26718337
- A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia. PMID: 26119399
- Knock-down of EGR2 with siRNA was demonstrated to have a similar effect as the over-expression of miR-330-3p in NSCLC cell lines PMID: 25935837
- Dysregulated Egr-2 is observed in some human autoimmune disorders. PMID: 25381473
- EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced regression of Ewing sarcoma xenografts. PMID: 26214589
- transcription factor early growth response gene-2 is a novel molecular switch regulating known immunomodulatory molecules in human mesenchymal stem cells. PMID: 24007274
- Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a. PMID: 23924943
- Lack of association of EGR2 variants with bipolar disorder in Japanese population. PMID: 23747400
- EGR2 and EGR3 are regulated by NFkappaB and MAPK signalling pathways downstream of TNFalpha stimulation in breast adipose fibroblasts, and this in turn is upstream of CYP19A1 transcription via PI.4 PMID: 23485457
- data suggest a tendency of gender-specific association of EGR2 and EGR4 in schizophrenia. PMID: 22691714
- Charcot-Marie-Tooth neuropathy due to a novel EGR2 gene mutation exhibits a mild phenotype in a Czech family. PMID: 22546699
- Egr2 expression is translationally regulated via an IRES element, which is responsive to an inflammatory environment. PMID: 22915601
- we report on a heterozygous mutation in EGR2 in a family with a mild demyelinating form of adult-onset Charcot-Marie-Tooth disease PMID: 22734907
- Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in bipolar disorder. PMID: 22089088
- data further demonstrate the major role of the myelinating Schwann cell element in the regulation of EGR2 expression in the human peripheral nervous system PMID: 22522483
- Results identify a mutation in EGR2 in a Charcot-Marie-tooth disease patient with hypersensitivity to vincristine. PMID: 22271166
- Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. PMID: 22327514
- Krox20 functions as a SUMO ligase for its coregulators--the Nab proteins--and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. PMID: 21836637
- TGF-beta3 regulated Egr-2 gene expression in uterine leiomyoma cells. PMID: 21703609
- these findings suggest that Egr-2 plays an important nonredundant role in the pathogenesis of fibrosis. PMID: 21514423
- EGR2 is a direct transcriptional target of p53 family that can in part mediate the p53-dependent apoptotic pathway. PMID: 21042708
- Schwann cells expressed myelin proteins and Krox20 which is an important regulator of peripheral myelination. PMID: 21057508
- EGR2 is a genetic risk factor for Systemic lupus erythematosus (SLE), in which increased gene expression may contribute to SLE pathogenesis. PMID: 20194224
- EGR2 mutation(amino aacid substitution) identifies a case of Charcot-Marie-Totth disease. PMID: 20513111
- overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2. PMID: 20067763
- Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies PMID: 12471219
- EGR2 mutant D355V induces a Cx32 promoter, mutant R381H doesn't. A sequence located at -216, recognized by the wild-type and the mutant D355V recombinant proteins, is relevant for promoter transactivation. PMID: 12609493
- we found that EGR2 could induce apoptosis in a large proportion of these lines by altering the permeability of mitochondrial membranes, releasing cytochrome c and activating caspase-3, -8, and -9. PMID: 12687019
- This report detected a heterozygous Asp383Tyr mutation of EGR2 in one patient with severe CMT1, Dejerine-Sottas syndrome. PMID: 12736090
- a possible molecular mechanism to account for down-regulation of EGR2 in tumor cells PMID: 14596916
- Egr-2 and Egr-3 transcription is enhanced by Hepatitis B virus X protein, which induces fasL gene expression PMID: 15173177
- A Charcot-Marie-Tooth syndrome in a family with a missense mutation in EGR2. PMID: 15947997
- One novel de-novo mutation (Arg359Gln, R359Q) was identified in heterozygous state in a patient with a typical CMT1 phenotype, progressive moderate thoracolumbar scoliosis and without clinical signs of cranial nerve dysfunction. PMID: 16198564
- Control of Krox20 transcription relies on three very long-range enhancer elements (A, B and C) that are conserved in chick, mouse and human genomes. PMID: 16495311
- morphological studies in the context of the I268N homozygous recessive mutation affecting the NAB repressor binding site and the R359W dominant-negative mutation in the zinc-finger domain PMID: 17717711
- Collectively, these data indicate that EGR2 is specifically upregulated by a parasite-derived secreted factor that is most likely a resident rhoptry protein. PMID: 18678671
- Dysregulation of EGR2 and MeCP2 plays roles in in Rett syndrome and autism. PMID: 19000991
- AIP2 regulates activation-induced T-cell death by suppressing EGR2-mediated FasL expression via the ubiquitin pathway PMID: 19651900
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相關疾病：Neuropathy, congenital hypomyelinating or amyelinating (CHN); Charcot-Marie-Tooth disease 1D (CMT1D); Dejerine-Sottas syndrome (DSS)
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亞細胞定位：Nucleus.
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蛋白家族：EGR C2H2-type zinc-finger protein family
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數據庫鏈接：
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