Dio3 Antibody

^{Rare Species}

中文名稱：

Dio3兔多克隆抗體
貨號：

CSB-PA344617LA01RA
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Rattus norvegicus (Rat) Dio3 Polyclonal antibody
Uniprot No.：

P49897
基因名：

Dio3
別名：

Dio3 antibody; Itdi3 antibody; Txdi3 antibody; Thyroxine 5-deiodinase antibody; EC 1.21.99.3 antibody; 5DIII antibody; DIOIII antibody; Type 3 DI antibody; Type III iodothyronine deiodinase antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，Dio3 Antibody (CSB-PA344617LA01RA)，的標記方式是Non-conjugated。對于Dio3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA344617LB01RA	Dio3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA344617LC01RA	Dio3 Antibody, FITC conjugated
Biotin	CSB-PA344617LD01RA	Dio3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
基因功能參考文獻：
1. findings suggest that translational repression of Dio3 is an important determinant of the reduced D3 protein expression following liver damage PMID: 23586759
2. ischemia/hypoxia induces an Hsp40-mediated translocation of Dio3 to the nucleus, facilitating thyroid hormone inactivation proximal to the thyroid hormone receptors PMID: 22723689
3. Data suggest that genetic background and sex modify vulnerability to prenatal alcohol via brain region-specific expression of Dio3. PMID: 21429942
4. we show marked expression of D3 by granulocytes and macrophages in spinal cord inflammatory lesions of EAE rats. We further confirm induction of D3 expression in vitro in monocytes that were activated toward proinflammatory or immunomodulatory phenotypes PMID: 19916870
5. Induction of D3 activity begins immediately after implantation and increases markedly over next 72 hours. In spontaneously cycling female rats, both D2 and D3 were observed to be 3- to 8-fold higher in proestrus, compared with diestrus. PMID: 12959985
6. genomic imprinting and gene expression at the Dlk1/Dio3 imprinted domain may play a role in the regulation of adipocyte proliferation and differentiation PMID: 17510246
7. Acute decrease in serum T(4) and T(3) after myocardial infarction is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart. PMID: 17628010
8. a mechanism of metabolic regulation during hypoxic-ischemic injury in which HIF-1 reduces local thyroid hormone signaling through induction of D3. PMID: 18259611
9. Dio3 is important in the modulation of thyroid hormone levels in the regenerating liver, in which decrease in cellular T3 permits an increase in proliferation. PMID: 18787028
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亞細胞定位：

Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
蛋白家族：

Iodothyronine deiodinase family
組織特異性：

Neonatal skin, placenta, skeletal muscle and cerebral cortex.
數(shù)據(jù)庫鏈接：

KEGG: rno:29475

UniGene: Rn.11237

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