DYNLRB1 Antibody, FITC conjugated
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中文名稱：DYNLRB1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA865093HC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DYNLRB1 Polyclonal antibody
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Uniprot No.：
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基因名：DYNLRB1
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別名：DYNLRB1 antibody; BITH antibody; DNCL2A antibody; DNLC2A antibody; ROBLD1 antibody; HSPC162Dynein light chain roadblock-type 1 antibody; Bithoraxoid-like protein antibody; BLP antibody; Dynein light chain 2A antibody; cytoplasmic antibody; Dynein-associated protein Km23 antibody; Roadblock domain-containing protein 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dynein light chain roadblock-type 1 protein (3-96AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
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基因功能參考文獻：
- Human colorectal carcinoma cells display decreased tumor progression and invasion when a novel anti-cell motility target, DYNLRB1, is being silenced. PMID: 23755307
- TGFbeta regulates km23-1 interaction with the R1beta regulatory subunit of protein kinase A. PMID: 23333499
- these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy. PMID: 23079622
- km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways PMID: 22637579
- Silencing of km23, either through somatic genetic mutation or promoter hypermethylation, is rare in ovarian, breast, and colorectal cancers. PMID: 16778097
- report the 2.1-A crystal structure of Dnlc2A using single anomalous diffraction PMID: 16970917
- Infrequently mutated in human colorectal and gastric cancers. PMID: 17556076
- DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
- Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. PMID: 19571232
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亞細胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：GAMAD family
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組織特異性：High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.
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數據庫鏈接：
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